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Anti-TACSTD2 (clone 7E6)-PEG6-MMAD ADC

Anti-TACSTD2 (clone 7E6)-PEG6-MMAD ADC (CAT#: ADC-W-292)

This ADC product is comprised of an anti-TACSTD2 monoclonal antibody (clone 7E6) conjugated via a PEG6 linker to MMAD. The MMAD is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAD binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

Product Information
ADC Target
ADC Antibody
ADC Linker
ADC payload drug

Antibody clone #
7E6

Name
TACSTD2

Alternative Names
TACSTD2; tumor-associated calcium signal transducer 2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic ca

Target Entrez Gene ID
4070

Target UniProt ID
P09758

Overview
This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.

Overview
Humanized Anti-TACSTD2 antibody, clone # 7E6

Clone #
7E6

Species Reactivity
Human

Name
PEG6 ((Propylene Glycol)-6-propionyl)

Description
Polyethylene glycol (PEG) is a polyether compound with many applications from industrial manufacturing to medicine. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight.

Name
MMAD (monomethyl auristatin D)

Description
Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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CAMouse™-Fully Human Antibody Generation Platform

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Same Target Same Payload

CAT#	Product Name	Linker	Payload
ADC-W-568	Anti-TACSTD2 (clone C16)-VC-MMAD ADC	VC (valine-citrulline)	MMAD (monomethyl auristatin D)
ADC-W-563	Anti-TACSTD2 (clone C16)-VC-PABC-Aur0101 ADC	VC-PABC (valine-citrulline-p-aminobenzylcarbamate)	Aur0101
ADC-W-293	Anti-TACSTD2 (clone 7E6)-AcLys-VC-PABC-0101	AcLys-VC- PABC (Acetyl-lysine-valine-citrulline-p-aminobenzyloxycarbonyl)	2-methylalanyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidin-1-yl}-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide)
ADC-W-539	Anti-TACSTD2 (clone C16)-PEG6-Aur3377 ADC	Amino-PEG6-based linker	Aur3377
ADC-W-290	Anti-TACSTD2 (clone 7E6)-AcLys-VC-PABC-MMAD ADC	AcLys-VC- PABC (Acetyl-lysine-valine-citrulline-p-aminobenzyloxycarbonyl)	MMAD (monomethyl auristatin D)

CAT#	Product Name	Linker	Payload
ADC-W-167	Anti-TPBG (L443C)-VC-MMAD ADC	VC (valine-citrulline)	MMAD (monomethyl auristatin D)
ADC-W-312	Anti-TPBG (clone A1)-hydroxyl amino PEG-MMAD ADC	hydroxyl amino PEG linker	MMAD (monomethyl auristatin D)
ADC-W-409	Anti-ERBB2 (Trastuzumab)-Mc-MMAD ADC	Mc (maleimidocaproyl)	MMAD (monomethyl auristatin D)
ADC-W-570	Anti-TACSTD2 (clone C16)-Mc-VC-MMAD ADC	Mc-VC (maleimidocaproyl-valine-alanine)	MMAD (monomethyl auristatin D)
ADC-W-568	Anti-TACSTD2 (clone C16)-VC-MMAD ADC	VC (valine-citrulline)	MMAD (monomethyl auristatin D)

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