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Anti-TNFRSF8 (CA10)-β-glucuronide-Camptothecin Analog ADC (CAT#: ADC-W-349)

This ADC product is comprised of an anti-TNFRSF8 monoclonal antibody (CA10) conjugated via a β-glucuronide linker to a Camptothecin Analog.

  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Name
  • TNFRSF8
  • Alternative Names
  • TNFRSF8; tumor necrosis factor receptor superfamily, member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30;
  • Target Entrez Gene ID
  • 943
  • Overview
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
  • Overview
  • Chimeric Anti-TNFRSF8 Antibody, cAC10
  • Generic name
  • cAC10
  • Species Reactivity
  • Human
  • Name
  • β-glucuronide linker
  • Description
  • β-Glucuronide linkers belong to Enzymatically cleavable linkers, which have expected stability and provide facile release of the active drug. The cleavage of the β-glucuronide glycosidic bond relies on lysosomal enzyme β-glucuronidase, and this enzyme is abundantly present within lysosomes and is overexpressed in some tumor types, while the enzyme activity outside cells is low.
  • Name
  • Camptothecin Analog
  • Description
  • Calicheamicin,produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.

For Research Use Only. NOT FOR CLINICAL USE.

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CAT# Product Name Linker Payload
ADC-W-372 Anti-CD70 (clone h1F6)-β-glucuronide-Camptothecin Analog ADC β-glucuronide linker Camptothecin Analog

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