- Home
- Products
- Customized ADCs
- CD70
- Anti-CD70 (clone h1F6)-β-glucuronide-Camptothecin Analog ADC
Anti-CD70 (clone h1F6)-β-glucuronide-Camptothecin Analog ADC (CAT#: ADC-W-372)
This ADC product is comprised of an anti-CD70 monoclonal antibody (clone h1F6) conjugated via a β-glucuronide linker to a Camptothecin Analog. The Camptothecin Analog is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Antibody clone #
- h1F6
- Name
- CD70
- Alternative Names
- CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7;
- Target Entrez Gene ID
- 970
- Target UniProt ID
- P32970
- Overview
- The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
- Overview
- Humanized Anti-CD70 lgG1 Antibody, clone # h1f6
- Clone #
- h1F6
- Species Reactivity
- Human
- Name
- β-glucuronide linker
- Description
- β-Glucuronide linkers belong to Enzymatically cleavable linkers, which have expected stability and provide facile release of the active drug. The cleavage of the β-glucuronide glycosidic bond relies on lysosomal enzyme β-glucuronidase, and this enzyme is abundantly present within lysosomes and is overexpressed in some tumor types, while the enzyme activity outside cells is low.
- Name
- Camptothecin Analog
- Description
- Calicheamicin,produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
- Anti-CD79b (SN8)-MCC-DM1 ADC (CAT#: ADC-W-223)
- Anti-EGFR (clone Bat0206)-S-3AA-MDC ADC (CAT#: ADC-W-126)
- Anti-TNFRSF8 (CA10)-β-glucuronide-Camptothecin Analog ADC (CAT#: ADC-W-349)
- Anti-TFPI (Concizumab)-MC-MMAF ADC (CAT#: ADC-W-1792)
- Anti-TNF (Certolizumab pegol)-SMCC-DM1 ADC (CAT#: ADC-W-1844)
- Anti-IFNA1 (Faralimomab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (CAT#: ADC-W-1225)
- Anti-AFP (Tacatuzumab)-SMCC-DM1 ADC (CAT#: ADC-W-656)
- Anti-TNFRSF8 (Brentuximab-LC-K149)-DBCO-MMAF ADC (CAT#: ADC-W-263)
- Anti-CD79b (clone 10D10)-MCC-DM1 ADC (CAT#: ADC-W-237)
- Anti-IL23A (Tildrakizumab)-MC-Vc-PAB-MMAE ADC (CAT#: ADC-W-1355)
Published Data
+ Submit Publications
Scientific Resources
Customer Reviews and FAQs
There are currently no Customer reviews or questions for ADC-W-372. Click the button above to contact us or submit your feedback about this product.
Quick Links
Other Products
Same Target
Same Linker
Same Payload
CAT# | Product Name | Linker | Payload |
ADC-W-954 | Anti-CD70 (Vorsetuzumab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
ADC-W-950 | Anti-CD70 (Vorsetuzumab)-SMCC-DM1 ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
ADC-W-446 | Anti-CD70 (clone h1F6)-Mc-VC-PBD ADC | mc-VC (maleimidocaproyl-valine-citrulline) | pyrrolobenzodiazepine (PBD) dimers |
ADC-W-376 | Anti-CD70 (clone h1F6)-β-glucuronide-doxorubicin ADC | β-glucuronide linker | doxorubicin |
ADC-W-573 | Anti-CD70 (clone h1F6239C)-PBD ADC | maleimidocaproyl-valine-alanine | pyrrolobenzodiazepine (PBD) |
CAT# | Product Name | Linker | Payload |
ADC-W-374 | Anti-CD70 (clone h1F6)-β-glucuronide-MMAE ADC | β-glucuronide linker | MMAE (Monomethyl auristatin E) |
ADC-W-352 | Anti-TNFRSF8 (cCA10)-β-glucuronide-MMAF ADC | β-glucuronide linker | MMAF (Monomethyl auristatin F) |
ADC-W-353 | Anti-TNFRSF8 (cCA10)-β-glucuronide-doxorubicin propyloxazoline (DPO) ADC | β-glucuronide linker | doxorubicin propyloxazoline (DPO) |
ADC-W-375 | Anti-CD70 (clone h1F6)-β-glucuronide-MMAF ADC | β-glucuronide linker | MMAF (Monomethyl auristatin F) |
ADC-W-376 | Anti-CD70 (clone h1F6)-β-glucuronide-doxorubicin ADC | β-glucuronide linker | doxorubicin |
CAT# | Product Name | Linker | Payload |
ADC-W-349 | Anti-TNFRSF8 (CA10)-β-glucuronide-Camptothecin Analog ADC | β-glucuronide linker | Camptothecin Analog |
Online Inquiry
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.