ADC Linker Products

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Product Overview

Creative Biolabs offers a variety of chemically versatile linker molecules to facilitate antibody-drug conjugate (ADC) development projects. All chemical linkers are of >95% purity and they are the basic building blocks for a successful ADC. Linkers facilitate the conjugation of ADC toxins to antibodies and in the meantime, they also dictate the release mechanism of an ADC. Proper linker selection will not only ease the process of obtaining the conjugate but also help enhance the chemical and serum stability of the ADC. Creative Biolabs carries a series of cleavable linkers (pH-sensitive linkers, disulfide linker, peptide linkers, β-glucuronide linkers), non-cleavable linkers, and intermediate linker modules. In the meantime, we also offer the services in the DrugLnk synthesis platform to prepare customized linkers with unique structures.

ADC Linker Services

Creative Biolabs offers a comprehensive "DrugLnk" linker module designed to cater to the diverse needs of antibody-drug conjugate (ADC) development. This module focuses on the design and preparation of various types of linkers, tailored to their specific drug release mechanisms. Clients can choose from a range of linker types:

Leveraging an advanced synthetic chemistry platform along with an extensive inventory of toxins, linkers, and drug-linker sets, "DrugLnk" at Creative Biolabs enables our skilled chemists to provide specialized services.

(1) Design linkers with optimal size
(2) Select linkers with suitable release mechanism
(3) Engineer linkers with compatible conjugation chemistry
(4) Synthesize customized linkers
(5) Modify payload drug
(6) Design synthesis routes
(7) Synthesize customized drug-linker complexes

Please feel free to contact us for more information about our ADC linker services.

Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform

Global Antibody-drug Conjugate (ADC) Clinical Trial ReviewGlobal Antibody-drug Conjugate (ADC) Clinical Trial Review 2018.3

Creative Biolabs ADC Product Brochure

Protocol

Quick Links

ADC Toxins

Drug-linker Complexes

Customized ADCs

Anti-Ab ADCs

Product List

Functional Group 1:

Reactive Group 1:

Click Chemistry Group 1:

Functional Group 2:

Reactive Group 2:

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PEG/Non-PEG:

Cleavable/Non-Cleavable:

Catalog	Product name	CAS NO	Structure	Molecular Weight	Purity	Data sheet	Inquiry
ADC-L-Y0125	DBCO-C6-acid	1425485-72-8		333.4	95%		Inquiry
ADC-L-Y0127	DBCO-NHCO-PEG13-NHS ester			1046.2	95%		Inquiry
ADC-L-Y0128	DBCO-C3-PEG4-amine			609.7	95%		Inquiry
ADC-L-Y0129	DBCO-PEG10-DBCO	2096516-12-8		1075.3	95%		Inquiry
ADC-L-Y0133	Amino-PEG4-acid	663921-15-1		265.3	95%		Inquiry
ADC-L-Y0134	Amino-PEG5-acid	1191078-74-6		309.4	95%		Inquiry
ADC-L-Y0135	Amino-PEG6-acid	905954-28-1		353.4	95%		Inquiry
ADC-L-Y0136	Amino-PEG8-acid	756526-04-2		441.5	95%		Inquiry
ADC-L-Y0137	Amino-PEG9-acid	1191079-83-0		484.6	95%		Inquiry
ADC-L-Y0138	Amino-PEG10-acid	196936-04-6		529.6	95%		Inquiry
ADC-L-Y0139	Amino-PEG12-acid	196936-04-6		617.7	95%		Inquiry
ADC-L-Y0140	Amino-PEG16-acid	196936-04-6		794	95%		Inquiry
ADC-L-Y0141	Amino-PEG20-acid HCl salt			970.2	95%		Inquiry
ADC-L-Y0142	Amino-PEG23-acid HCl salt	196936-04-6		1102.3	95%		Inquiry
ADC-L-Y0143	Amino-PEG24-acid HCl salt	196936-04-6		1146.4	95%		Inquiry
ADC-L-Y0144	Amino-PEG25-acid HCl salt	196936-04-6		1190.4	95%		Inquiry
ADC-L-Y0145	Amino-PEG28-acid	196936-04-6		1322.6	95%		Inquiry
ADC-L-Y0146	Amino-PEG32-acid	196936-04-6		1498.8	95%		Inquiry
ADC-L-Y0147	Amino-PEG36-acid	196936-04-6		1675	95%		Inquiry
ADC-L-Y0149	Amino-PEG3-CH2CO2H	134978-99-7		207.2	95%		Inquiry