ADC Linker Products

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Product Overview

Creative Biolabs offers a variety of chemically versatile linker molecules to facilitate antibody-drug conjugate (ADC) development projects. All chemical linkers are of >95% purity and they are the basic building blocks for a successful ADC. Linkers facilitate the conjugation of ADC toxins to antibodies and in the meantime, they also dictate the release mechanism of an ADC. Proper linker selection will not only ease the process of obtaining the conjugate but also help enhance the chemical and serum stability of the ADC. Creative Biolabs carries a series of cleavable linkers (pH-sensitive linkers, disulfide linker, peptide linkers, β-glucuronide linkers), non-cleavable linkers, and intermediate linker modules. In the meantime, we also offer the services in the DrugLnk synthesis platform to prepare customized linkers with unique structures.

ADC Linker Services

Creative Biolabs offers a comprehensive "DrugLnk" linker module designed to cater to the diverse needs of antibody-drug conjugate (ADC) development. This module focuses on the design and preparation of various types of linkers, tailored to their specific drug release mechanisms. Clients can choose from a range of linker types:

Leveraging an advanced synthetic chemistry platform along with an extensive inventory of toxins, linkers, and drug-linker sets, "DrugLnk" at Creative Biolabs enables our skilled chemists to provide specialized services.

(1) Design linkers with optimal size
(2) Select linkers with suitable release mechanism
(3) Engineer linkers with compatible conjugation chemistry
(4) Synthesize customized linkers
(5) Modify payload drug
(6) Design synthesis routes
(7) Synthesize customized drug-linker complexes

Please feel free to contact us for more information about our ADC linker services.

Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform

Global Antibody-drug Conjugate (ADC) Clinical Trial ReviewGlobal Antibody-drug Conjugate (ADC) Clinical Trial Review 2018.3

Creative Biolabs ADC Product Brochure

Protocol

Quick Links

ADC Toxins

Drug-linker Complexes

Customized ADCs

Anti-Ab ADCs

Product List

Functional Group 1:

Reactive Group 1:

Click Chemistry Group 1:

Functional Group 2:

Reactive Group 2:

Click Chemistry Group 2:

PEG/Non-PEG:

Cleavable/Non-Cleavable:

Catalog	Product name	CAS NO	Structure	Molecular Weight	Purity	Data sheet	Inquiry
ADC-L-Y0173	Amino-PEG5-amine	72236-26-1		280.4	95%		Inquiry
ADC-L-Y0174	Amino-PEG6-amine	76927-70-3		324.4	95%		Inquiry
ADC-L-Y0175	Amino-PEG7-amine	332941-25-0		368.5	95%		Inquiry
ADC-L-Y0176	Amino-PEG8-amine	82209-36-7		412.5	95%		Inquiry
ADC-L-Y0177	Amino-PEG9-amine	474082-35-4		456.6	95%		Inquiry
ADC-L-Y0178	Amino-PEG10-amine	928292-69-7		500.6	95%		Inquiry
ADC-L-Y0179	Amino-PEG11-amine	479200-82-3		544.7	95%		Inquiry
ADC-L-Y0180	Amino-PEG23-amine	24991-53-5		1073.3	95%		Inquiry
ADC-L-Y0182	Azido-PEG2-amine	166388-57-4		174.2	95%		Inquiry
ADC-L-Y0184	Azido-PEG4-amine	951671-92-4		262.3	95%		Inquiry
ADC-L-Y0185	Azido-PEG5-amine	516493-93-9		306.4	95%		Inquiry
ADC-L-Y0186	Azido-PEG6-amine	957486-82-7		350.4	95%		Inquiry
ADC-L-Y0187	Azido-PEG7-amine	1333154-77-0		394.5	95%		Inquiry
ADC-L-Y0188	Azido-PEG8-amine	857891-82-8		438.5	95%		Inquiry
ADC-L-Y0189	Azido-PEG9-amine	1207714-69-9		482.6	95%		Inquiry
ADC-L-Y0190	Azido-PEG10-amine	912849-73-1		526.6	95%		Inquiry
ADC-L-Y0191	Azido-PEG11-amine	1800414-71-4		570.7	95%		Inquiry
ADC-L-Y0192	Azido-PEG23-amine	749244-38-0		1099.3	95%		Inquiry
ADC-L-Y0193	Azido-PEG35-amine	749244-38-0		1628	95%		Inquiry
ADC-L-Y0197	Amino-PEG4-t-Boc-hydrazide	1263047-17-1		379.5	95%		Inquiry