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Anti-EFNA4 (clone huE47)-AcBut-CM ADC (CAT#: ADC-W-019)

This ADC product is comprised of an anti-EFNA4 monoclonal antibody (clone huE47)) conjugated via an AcBut linker to CM. The CM is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis.

  • Product Information
  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Antibody clone #
  • huE47
  • Name
  • EFNA4
  • Alternative Names
  • ephrin-A4; EFL4; EPLG4; LERK4; LERK-4; ligand of eph-related kinase 4; eph-related receptor tyrosine kinase ligand 4;
  • Target Entrez Gene ID
  • 1945
  • Overview
  • This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified.
  • Overview
  • Anti-EFNA4-antibody, clone # huE47
  • Clone #
  • huE47
  • Species Reactivity
  • Human
  • Name
  •  AcBut [-(4' acetyl phenoxy) butanoic acid]
  • Description
  • Disulfide Linkers, are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
  • Name
  • CM (N-acetyl-y-calicheamicin dimethyl hydrazide)

For Research Use Only. NOT FOR CLINICAL USE.

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Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform
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Development of Monoclonal Antibodies
Literature
CAMouse™-Fully Human Antibody Generation Platform
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Other Products

Same Target Same Linker Same Payload
CAT# Product Name Linker Payload
ADC-W-018 Anti-EFNA4 (clone huE22)-AcBut-CM ADC  AcBut [-(4' acetyl phenoxy) butanoic acid] CM (N-acetyl-y-calicheamicin dimethyl hydrazide)
CAT# Product Name Linker Payload
ADC-W-008 Anti-TPBG (clone A1)-AcBut-calicheamicin ADC  AcBut [-(4' acetyl phenoxy) butanoic acid] calicheamicin
ADC-W-332 Anti-CD22 (clone 10F4)-AcBut-Calicheamicin ADC  AcBut [-(4' acetyl phenoxy) butanoic acid] calicheamicin
ADC-W-459 Anti-FUT3 (clone hu3S193)-AcBut-CalichDMH ADC  AcBut [-(4' acetyl phenoxy) butanoic acid] CalichDMH
ADC-W-018 Anti-EFNA4 (clone huE22)-AcBut-CM ADC  AcBut [-(4' acetyl phenoxy) butanoic acid] CM (N-acetyl-y-calicheamicin dimethyl hydrazide)
ADC-W-357 Anti-CD33 (clone HuM195)-AcBut-Calicheamicin ADC  AcBut [-(4' acetyl phenoxy) butanoic acid] calicheamicin
CAT# Product Name Linker Payload
ADC-W-018 Anti-EFNA4 (clone huE22)-AcBut-CM ADC  AcBut [-(4' acetyl phenoxy) butanoic acid] CM (N-acetyl-y-calicheamicin dimethyl hydrazide)

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