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STEAP1
Anti-STEAP1-Mc-VC-PABC-MMAE ADC

Anti-STEAP1-Mc-VC-PABC-MMAE ADC (CAT#: ADC-W-436)

This ADC product is comprised of an anti-STEAP1 monoclonal antibody conjugated via a Mc-VC-PABC linker to MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

ADC Target
ADC Antibody
ADC Linker
ADC payload drug

Name
STEAP1

Alternative Names
STEAP1; six transmembrane epithelial antigen of the prostate 1; STEAP; PRSS24; metalloreductase STEAP1; six-transmembrane epithelial antigen of prostate 1;

Target Entrez Gene ID
26872

Target UniProt ID
Q9UHE8

Overview
This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.

Overview
Anti-STEAP1 Antibody

Species Reactivity
Human

Name
MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)

Description
Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

Name
MMAE (Monomethyl auristatin E)

Description
Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform

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Other Products

Same Target Same Linker Same Payload

CAT#	Product Name	Linker	Payload
ADC-W-591	Anti-STEAP1-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)

CAT#	Product Name	Linker	Payload
ADC-W-607	Anti-ERBB2-Mc-VC-PABC-MMAE ADC	MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)	MMAE (Monomethyl auristatin E)
ADC-W-506	Anti-VTCN1 (clone h1D11)-MC-vc-PABC-MMAE ADC	MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)	MMAE (Monomethyl auristatin E)
ADC-W-456	Anti-MSLN (clone h7D9.v3)-Mc-VC-PABC-MMAF ADC	MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)	MMAF (Monomethyl auristatin F)
ADC-W-587	Anti-CD70 (clone h1F6 )-Mc-VC-PABC-MMAE ADC	MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)	MMAE (Monomethyl auristatin E)
ADC-W-501	Anti-FcrL5 (clone 13G9)-Mc-VC-PABC-MMAE ADC	MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)	MMAE (Monomethyl auristatin E)

CAT#	Product Name	Linker	Payload
ADC-AA-017	anti-HIgG(Fab)-C-MMAE ADC	Cleavable linkers	MMAE (Monomethyl auristatin E)
ADC-W-536	Anti-EDNRB (endothelin B)-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-AA-003	anti-HIgG(Fc)-C-MMAE ADC	Cleavable linkers	MMAE (Monomethyl auristatin E)
ADC-AA-011	anti-HIgG(Fc)Fab-C-MMAE ADC	Cleavable linkers	MMAE (Monomethyl auristatin E)
ADC-W-465	Anti-TNFRSF8 (Brentuximab)-VC-PAB-MMAE ADC	VC-PAB (valine-citrulline with PAB)	MMAE (Monomethyl auristatin E)

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