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- anti-HIgG(Fc)Fab-C-MMAE ADC
anti-HIgG(Fc)Fab-C-MMAE ADC (CAT#: ADC-AA-011)
This ADC product is comprised of a Fab fragment of an anti-human IgG Fc specific polyclonal antibody conjugated via a cleavable linker to MMAE. The antibody portion is a Fab fragment of a secondary antibody and the drug portion, MMAE, is a cytotoxic small molecule which binds to tubulins, interrupts microtubule dynamics, and induces cell death. This product displays no obvious toxicity without a primary antibody and can be a quite efficient and economical alternative to pre-screening human monoclonal antibodies as ADC candidates.
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Name
- IgG Fc
- Overview
- The fragment crystallizable region (Fc region) is composed of the constant region of the two heavy chains that form the IgG molecule. The Fc region of IgG bears a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. Fc binds to various cell receptors and complement proteins thus mediating different physiological effects of antibodies, such as opsonization, antibody dependent cellular cytotoxicity (ADCC), degranulation of mast cells, basophils, eosinophils and other processes.
- Overview
- Fab fragment of anti-human IgG Fc specific polyclonal antibody
- Species Reactivity
- Human
- Name
- Cleavable linkers
- Description
- Cleavable linkers rely on the physiological stimuli, which mainly include chemically cleavable linkers and enzymatically cleavable linkers. Chemically cleavable linkers including acid-labile linkers and disulfide linkers. For acid-labile linkers, intracellular release of payloads relies on the different pH between endosomes/lysosomes and blood. The release of disulfide-linked drugs is controlled by the factors in intracellular environment. Enzymatically cleavable linkers, peptide linkers and β-glucuronide linkers, are sensitive to enzymes located in cytoplasm.
- Name
- MMAE (Monomethyl auristatin E)
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
- Anti-HIgG(Fab)-N-MMAF ADC (CAT#: ADC-AA-063)
- anti-RIgG(HL)Fab-N-MMAF ADC (CAT#: ADC-AA-037)
- Anti-HIgG(Fab)-C-MMAF ADC (CAT#: ADC-AA-064)
- anti-MIgG(Fc)-C-DMDM ADC (CAT#: ADC-AA-024)
- anti-RIgG(Fc)-N-MMAF ADC (CAT#: ADC-AA-032)
- anti-HIgG(Fc)Fab-C-DMDM ADC (CAT#: ADC-AA-013)
- anti-HIgG(Fc)Fab-C-MMAF ADC (CAT#: ADC-AA-010)
- anti-Rat IgG(Fc)-C-MMAF ADC (CAT#: ADC-AA-040)
- anti-MIgG(Fc)Fab-N-DM1 ADC (CAT#: ADC-AA-031)
- anti-HIgG(Fc)-C-DMSA ADC (CAT#: ADC-AA-005)
Published Data
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Scientific Resources
Customer Reviews and FAQs
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Customer Reviews
FAQ
Excellent
Highly effective! The anti-HIgG(Fc)Fab-C-MMAE ADC product exhibited outstanding specificity in our assays. Consistently reliable results with minimal background interference. Highly recommended!
Excellent
Top-notch performance Excellent conjugation efficiency and stability. The product surpassed our expectations in both in vitro and in vivo applications.
Excellent
Superior quality The ADC demonstrated remarkable potency and target specificity. Our research outcomes were significantly improved due to its effectiveness.
Excellent
Reliable and efficient Great product with consistent batch-to-batch performance. Simplified our workflow and delivered accurate results each time.
Excellent
Exceptional results The antibody-drug conjugate provided excellent cytotoxicity in our cell line studies. Delivery and packaging were impeccable.
Excellent
Highly recommend The anti-HIgG(Fc)Fab-C-MMAE ADC significantly enhanced our experimental throughput. Excellent quality and reliable performance in diverse applications.
Quick Links
Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-AA-053 | Protein A-MMAF ADC | MMAF (Monomethyl auristatin F) | |
| ADC-AA-056 | Anti-MIgG (clone 187.1)-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-AA-029 | anti-MIgG(Fc)Fab-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-AA-050 | Protein G-MCC-DM1 ADC | MCC (Maleimidomethyl cyclohexane-1-carboxylate) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-AA-026 | anti-MIgG(Fc)-N-DM1 ADC | Noncleavable linkers | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-003 | anti-HIgG(Fc)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-AA-066 | Anti-Rat IgG(H+L)-C-PBD ADC | Cleavable linkers | PBD (pyrrolobenzodiazepine) |
| ADC-AA-064 | Anti-HIgG(Fab)-C-MMAF ADC | Cleavable linkers | MMAF |
| ADC-AA-010 | anti-HIgG(Fc)Fab-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-AA-028 | anti-MIgG(Fc)Fab-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-056 | Anti-MIgG (clone 187.1)-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-536 | Anti-EDNRB (endothelin B)-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-AA-048 | Protein G-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-AA-021 | anti-MIgG(Fc)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-W-494 | Anti-SLC39A6-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
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