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anti-HIgG(Fc)-C-MMAE ADC (CAT#: ADC-AA-003)
This ADC product is comprised of an anti-human IgG Fc specific polyclonal antibody conjugated via a cleavable linker to MMAE. The antibody portion is a secondary antibody and the drug portion, MMAE, is a cytotoxic small molecule which binds to tubulins, interrupts microtubule dynamics, and induces cell death. This product displays no obvious toxicity without a primary antibody and can be a quite efficient and economical alternative to pre-screening human monoclonal antibodies as ADC candidates.
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Name
- IgG Fc
- Overview
- The fragment crystallizable region (Fc region) is composed of the constant region of the two heavy chains that form the IgG molecule. The Fc region of IgG bears a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. Fc binds to various cell receptors and complement proteins thus mediating different physiological effects of antibodies, such as opsonization, antibody dependent cellular cytotoxicity (ADCC), degranulation of mast cells, basophils, eosinophils and other processes.
- Overview
- anti-human IgG Fc specific polyclonal IgG antibody
- Species Reactivity
- Human
- Name
- Cleavable linkers
- Description
- Cleavable linkers rely on the physiological stimuli, which mainly include chemically cleavable linkers and enzymatically cleavable linkers. Chemically cleavable linkers including acid-labile linkers and disulfide linkers. For acid-labile linkers, intracellular release of payloads relies on the different pH between endosomes/lysosomes and blood. The release of disulfide-linked drugs is controlled by the factors in intracellular environment. Enzymatically cleavable linkers, peptide linkers and β-glucuronide linkers, are sensitive to enzymes located in cytoplasm.
- Name
- MMAE (Monomethyl auristatin E)
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
- anti-HIgG(Fc)Fab-N-DM1 ADC (CAT#: ADC-AA-015)
- Protein G-Amanitin ADC (CAT#: WJY-0423-LS108)
- Anti-MIgG(Fc)-C-DX8951 ADC (CAT#: ADC-AA-061)
- anti-Rat IgG(Fc)Fab-C-DMDM ADC (CAT#: ADC-AA-044)
- anti-Rat IgG(Fc)-C-MMAF ADC (CAT#: ADC-AA-040)
- Anti-MIgG (clone 187.1)-VC-MMAE ADC (CAT#: ADC-AA-056)
- anti-HIgG(Fc)Fab-N-AAMT ADC (CAT#: ADC-AA-016)
- anti-HIgG(Fc)-C-MMAF ADC (CAT#: ADC-AA-002)
- anti-MIgG(Fc)-C-DMSA ADC (CAT#: ADC-AA-023)
- anti-RIgG(HL)-N-MMAF ADC (CAT#: ADC-AA-034)
Published Data
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Scientific Resources
Customer Reviews and FAQs
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Customer Reviews
FAQ
Excellent
This ADC product exceeded my expectations. Its efficient targeting and minimal toxicity make it a superior choice for pre-screening monoclonal antibodies. Highly recommend!
Excellent
Using the anti-HIgG(Fc)-C-MMAE ADC has streamlined our research. The cleavable linker and MMAE combination effectively induce cell death with precision.
Excellent
The product's design, combining a polyclonal antibody with MMAE, ensures robust performance. It's cost-effective and highly efficient for ADC candidate screening.
Excellent
A fantastic product The secondary antibody's binding and the MMAE's cytotoxic effects make it a powerful tool in our laboratory.
Excellent
Impressed with the results The glycosylation of the Fc fragment enhances receptor-mediated activities, crucial for our experiments.
Excellent
Creative Biolabs has delivered a reliable ADC product. The anti-HIgG(Fc)-C-MMAE ADC is an excellent addition to our research toolkit, showing no obvious toxicity.
Quick Links
Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-AA-026 | anti-MIgG(Fc)-N-DM1 ADC | Noncleavable linkers | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-AA-031 | anti-MIgG(Fc)Fab-N-DM1 ADC | Noncleavable linkers | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-AA-021 | anti-MIgG(Fc)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-AA-049 | Protein G-MMAF ADC | MMAF (Monomethyl auristatin F) | |
| ADC-AA-054 | Protein A-MCC-DM1 ADC | MCC (Maleimidomethyl cyclohexane-1-carboxylate) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-066 | Anti-Rat IgG(H+L)-C-PBD ADC | Cleavable linkers | PBD (pyrrolobenzodiazepine) |
| ADC-AA-028 | anti-MIgG(Fc)Fab-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| WJY-0423-LS106 | Protein A-Calicheamicin ADC | Cleavable linkers | Calicheamicin |
| ADC-AA-017 | anti-HIgG(Fab)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-AA-064 | Anti-HIgG(Fab)-C-MMAF ADC | Cleavable linkers | MMAF |
| CAT# | Product Name | Linker | Payload |
| ADC-W-494 | Anti-SLC39A6-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-462 | Anti-GPNMB-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-AA-021 | anti-MIgG(Fc)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-AA-048 | Protein G-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-499 | Anti-SLC34A2 (Lifastuzumab)-VC-MMAE ADC | mc-VC-PABC | MMAE (Monomethyl auristatin E) |
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