Virus Sequencing and Analysis Service

In today's rapidly advancing field of biomedical science, understanding the nature of viruses has become an urgent task for the global scientific community. To address this challenge, Creative Biolabs is proud to introduce our cutting-edge viral sequencing and analysis services. The core objective of this service is to provide researchers and medical experts with accurate and efficient viral genetic analysis tools, aiding them in making decisive progress in the fight against viruses.

Fig.1 Characterization of the murine cytomegalovirus (MCMV) transcriptome.^1,2

Service Overview

Our viral sequencing and analysis service focuses on comprehensive and in-depth studies of certain viruses (details available upon request) and their analogues (such as pseudoviruses). Using the industry's most advanced sequencing platforms and bioinformatics tools, we offer our clients a range of services including but not limited to:

• Metavirome sequencing: Comprehensive identification of all virus-related genetic material in samples, both known and undiscovered viruses.
• RNA virus whole-genome sequencing: Reverse transcription and sequencing of RNA viruses to accurately analyze their genetic diversity and mutations.
• DNA virus whole-genome sequencing: High-throughput sequencing directly from viral DNA, annotating functional genes and studying viral evolution.
• Phage whole-genome sequencing: In-depth exploration of the interactions between phages and their host bacteria, providing new directions for antimicrobial research.

Viral Sequencing Process Display

1. Sample preparation: Extraction of viral genetic material
2. Sequencing library preparation
   • For RNA viruses, reverse transcription is performed to generate cDNA.
   • Fragment DNA and cDNA samples, adding adapters to prepare the sequencing library.
3. Sequencing
   Using high-throughput sequencing technology. This includes:
   • Low-to-medium throughput sequencing: Suitable for a small number of samples.
   • High-throughput sequencing: Suitable for large-scale samples.
4. Data analysis
5. Using bioinformatics tools for quality control, assembly, and alignment of sequencing data.
6. Applying specialized software for in-depth analysis, including variant detection, evolutionary analysis, etc.
   • For metavirome sequencing, metagenomic analysis is needed to identify all viral components.
   • Result interpretation and reporting

Interpreting sequencing data, generating reports, providing detailed information about viral characteristics and potential impacts.

Application Scope

Our viral sequencing and analysis services are widely applicable to various research and application fields, including but not limited to:

• Vaccine development: Providing critical genetic information and analysis support for vaccine research projects.
• Antiviral drug research: Assisting researchers in discovering and validating new antiviral drug targets.
• Viral pathogenesis research: Gaining deep insight into the interactions between viruses and host cells and their impact on pathological processes.
• Epidemiological studies: Supporting research on viral transmission and mutation patterns, enhancing predictive capabilities for epidemic trends.

Service Advantages

• Advanced technology: We use the latest NGS technology in the industry, capable of handling low to high throughput samples, catering to different scales of research needs.
• Professional team: Consisting of experienced biologists and data analysts, ensuring the professionalism and efficiency of our services.
• Rapid response: Swift service response to ensure the timeliness of research and monitoring work.
• Customer support: We provide comprehensive customer support services, including project consultation, data interpretation, follow-up services, etc., ensuring

At Creative Biolabs, we are committed to supporting and accelerating viral research worldwide through our viral sequencing and analysis services. We look forward to working with researchers and medical experts to contribute to the cause of human health and disease prevention. For further information about our services or to start a collaboration, please feel free to contact us.

References:

1. Lodha, M. et al. Decoding murine cytomegalovirus. PLoS Pathogens. 2023, 19(5):e1010992.
2. under Open Access license CC BY 4.0, without modification.

• Viral Recombinant Protein Production
• Virus Vector Design and Synthesis Service
• Pseudovirus Production
• Virus-Like Particles Production