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Dengue Virus S2 Virus-like Particles (DENV S2 VLPs) (CAT#: VLP-013YF)

Datasheet
Recombinant Dengue Virus serotype 2 Virus-like Particle (DENV S2 VLPs) are produced in mammalian HEK293 human cells, assembled with Envelope, pre-Membrane and Membrane proteins. VLP is mimicking the native 3D structure of viruses which can elicit strong immune responses. However, VLPs lack viral genomic material which makes them non-infectious, unable to replicate and enhance the safety during manufacture and administration. DENV S2 VLPs can be used in the development of DENV diagnostics and in vaccine development and R&D (including use as an immunogen).

Product Specifications

  • Structural Proteins
  • Capsid protein C, membrane protein M, envelope protein E
  • Expression Systems
  • HEK293 (please specify if other expression system is needed)
  • Purity
  • >95%
  • Buffer
  • 10 mM sodium phosphate, 20 mM sodium citrate, 154 mM sodium chloride, pH 7.4
  • Form
  • Liquid
  • Alternative Names
  • Dengue Virus S2 Virus-like Particle; DENV S2 VLPs; VLPs; Virus-like Particles; DENV Serotype 2; Dengue Virus Serotype 2
  • Storage
  • Store at -80 °C long term. Avoid repeated freeze/thaw cycles.

Virus Background

  • Virus Family
  • Flaviviridae
  • Virus Species
  • Dengue virus
  • Virus Overview
  • The DENV genome is about 11000 bases of positive-sense, single stranded RNA (ssRNA) that codes for three structural proteins (capsid protein C, membrane protein M, envelope protein E) and seven nonstructural proteins (NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5). It also includes short noncoding regions on both the 5' and 3' ends. Dengue virus (DENV) is the cause of dengue fever. It is a mosquito-borne, single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus. Five serotypes of the virus have been found, all of which can cause the full spectrum of disease.
  • Virus Structure
  • Enveloped, positive-sense, single-stranded RNA virus
  • Related Disease
  • Dengue disease

Customer reviews and Q&As    

Customer Review

Induction of immune response

Mice inoculated with DENV S2 VLP elicited a strong immune response.
2022-12-12

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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