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Premade Library based Binder Discovery Services

Premade Libraries Screening Services Approaches Advantages Cases

Creative Biolabs has constructed a variety of peptide and antibody libraries. These premade libraries accelerate the process of developing peptide and antibody detection reagents and drugs for our customers.

Premade Libraries

With years of experience in molecular biology operations and primer design, Creative Biolabs has built various high-quality libraries of multiple species and fragment types. We can use these libraries to provide screening services to our customers or license some of these libraries as products.

Fig. 1 A figure to show different formats of antibody fragments. (Creative Biolabs Original)

Antibody Libraries

HumanMouseRabbitChicken VHH (Camel, Llama, Alpaca) Humanized VHH
Antibody Library ID Display Technology Library Format Library Size
HuScL-6 pIII-fusion, Phagemid Phage Display Naïve scFv 2.1×1011
HuScL-7 pIII-fusion, Phagemid Phage Display Naïve scFv 1.1×1010
HuScL-3S pIII-fusion, Phagemid Phage Display Semi-synthetic scFv >1.0×1011
HuFabL-4 pIII-fusion, Phagemid Phage Display Naïve Fab 1.9×1010
HuFabL-5 pIII-fusion, Phagemid Phage Display Naïve Fab 1.1×1010
HuFabssL-1 pIII-fusion, Phagemid Phage Display Naïve & synthetic Fab 1.8×1010
HuscL-YDP-3 Yeast Display Naïve scFv 1.9×108
Antibody Library ID Display Technology Library Format Library Size
MuScL-2 pIII-fusion, Phagemid Phage Display Naïve scFv 5.3×1010
MuFabL-2 pIII-fusion, Phagemid Phage Display Naïve Fab 1.2×1010
Antibody Library ID Display Technology Library Format Library Size
RaFabL-1 pIII-fusion, Phagemid Phage Display Naïve Fab 7.5×109
RaFabL-2 pIII-fusion, Phagemid Phage Display Naïve Fab 1.2×1010
Antibody Library ID Display Technology Library Format Library Size
Chicken-ScL-2 pIII-fusion, Phagemid Phage Display Naïve scFv 1.1×1010
Antibody Library ID Display Technology Library Format Library Size
CaVHHL-4 pIII-fusion, Phagemid Phage Display Naïve VHH 2.63×1010
CaVHHL-5 pIII-fusion, Phagemid Phage Display Naïve VHH 3.0×1010
CaVHHL-6 pIII-fusion, Phagemid Phage Display Naïve VHH 2.43×109
LlaVHHL-1 pIII-fusion, Phagemid Phage Display Naïve VHH 2.0×109
LlaVHHL-2 pIII-fusion, Phagemid Phage Display Naïve VHH  1.8×1010
AlVHHL-1 pIII-fusion, Phagemid Phage Display Naïve VHH 1.35×1010
AlVHHL-2 pIII-fusion, Phagemid Phage Display Naïve VHH 1.5×1011
LlaVHHL-S1 pIII-fusion, Phagemid Phage Display Synthetic VHH 1.5×1011
CaVHHL-S2 pIII-fusion, Phagemid Phage Display Synthetic VHH 5.4×1010
CaVHHL-S3 pIII-fusion, Phagemid Phage Display Synthetic VHH 2.2×1010
CaVHHL-S4 pIII-fusion, Phagemid Phage Display Semi-synthetic VHH 5.3×1010
Antibody Library ID Display Technology Library Format Library Size
HuVHHL-S1 pIII-fusion, Phagemid Phage Display Synthetic VHH >1.0×1011
HuVHHL-S2 pIII-fusion, Phagemid Phage Display Semi-synthetic VHH >1.0×1010

Peptide Libraries

LinearCyclicOthers
Peptide Library ID Phage Display Library Format Library Size
TriCo-16 pIII-fusion, True Phage Display 16-mer peptide library 1.1×1010
TriCo-20 pIII-fusion, True Phage Display 20-mer peptide library 1.3×1010
Peptide Library ID Phage Display Library Format Library Size
TriCo-C9 pIII-fusion, Phagemid Phage Display Cyclic 9-mer peptide library 1.10×1010
TriCo-C9L pIII-fusion, Phagemid Phage Display Cyclic 9-mer peptide library 6.8×1010
Peptide Library ID Phage Display Library Format Library Size
Protease-10A pIII-fusion, Phagemid Phage Display HiAffi tagged 10 mer peptide library 1.10×1010

Premade Library based Screening Services

The high-quality premade libraries constructed by Creative Biolabs facilitate the discovery of peptide and antibody drugs. We can provide premade library screening services for different target types, such as peptides, proteins, and cells. In addition, thanks to many years of screening experience and multiple screening strategies, we can offer peptide and antibody drug development services targeting precise epitopes, such as receptor and ligand binding epitopes, TCR-like epitopes, and idiotypic epitopes. These screened binders are suitable for a variety of immunotherapies, such as CAR-T, bifunctional antibodies, ADC, and immune checkpoints.

Premade Antibody Library Screening Services

  • Functional Human Antibody Discovery
  • Various types of premade human antibody libraries
    Diverse genetic materials, high diversity libraries
    Large library capacity, >2.1x1011
    High affinity, from 10-7 to 10-9 M

Premade Peptide Library Screening Service

Screening Approaches

With decades of experience, scientists at Creative Biolabs specialize in library screening projects. We have established a variety of screening strategies to achieve customized goals best:

Advantages of Premade Library

Compared to other approaches, premade libraries offer several advantages:

Time Efficiency - Creative Biolabs provides customers with a rich selection of ready-to-use premade libraries. It saves time on sample collection and library construction. This speeds up the development process of ideal binders and allows you to focus more on the unique aspects of your application.

High Quality & Reliability – Creative Biolabs can construct large-capacity and high-diversity libraries and conduct strict quality control and batch management on the libraries, thereby improving the screening success rate.

Cost-Effectiveness - Using premade libraries can reduce the cost of building libraries, thereby reducing development costs.

Species Suitability - Human-derived premade antibody library avoids the subsequent humanization process. And the antibodies obtained from the naïve antibody library have good developability.

Cases

Case 1- Internalization Antibody Discovery from a Premade Phage Display Human Antibody Library

Fig. 2 A FACS data indicates an internalization antibody discovered from a premade phage display human antibody library was observed to internalize into both human and mouse target cells specifically. (Creative Biolabs Original)

Results

The selected candidate antibody from a premade human antibody library was observed to internalize into both human and mouse target cells specifically, indicating that the discovery of internalization antibody was successful.

Case 2 - Premade Antibody Library Screening for MHC-Peptide Complex

Fig. 3 A ELISA data shows there are 7 unique clones identified from premade libarary to recognize the target MHC-peptide positively. (Creative Biolabs Original)

Results

7 unique clones were identified to recognize the target MHC-peptide positively.


All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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