shRNA Adenovirus Serotype 5 (ΔE1/E3), p7SK-(FAM49B-shRNA-Seq2)(CAT#: AdV-SI1178WQ)

This product is a FAM49B-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. FAM49B is a regulator of mitochondrial function and integrity and also inhibits T-cell activation by repressing RAC1 activity and modulating cytoskeleton reorganization. The expression of FAM49B-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.

Specifications
Family Adenoviridae
Species Adenovirus
Serotype HAdV-5
Backbone AdV-5 (ΔE1/E3)
Tropism Both nondividing and dividing cells
Insert FAM49B-shRNA-Seq2
Related Target/Protein FAM49B
Region CDS
TargetSeq GCAAATCGAATGTCTTTGTTT
NCBI RefSeq NM_016623
Alternative Names L1; BM-009
Titer >1*10^10 GC/mL
Related Diseases Pancreatic ductal adenocarcinoma (PDAC)
Target Gene
Gene ID 51571
Uniprot ID Q9NUQ9

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