In Vivo Drug Metabolism and Pharmacokinetics (DMPK) Service

As an experienced end-to-end CRO in the field of cancer immunotherapy discovery and development, Creative Biolabs has emerged as a stable and trusted partner to provide integrated drug metabolism and pharmacokinetics (DMPK) services to support pre-clinical testing. PK is a critical aspect of pharmacology related to the study of drug action in animal models.

Accelerate and Innovate Your DMPK Studies to Best Maximize
Your Cancer Immunotherapeutic Drug Candidate!

In Vivo DMPK Services

Pharmacokinetics describes plasma concentration changes over time as a consequence of absorption, distribution, metabolism, and excretion (ADME). Our in vivo DMPK services can seamlessly perform in vivo sample generation as well as bioanalysis to determine how the body reacts to the drug. Creative Biolabs can product DMPK studies in most rodent species, and owns various instruments and expertise in our bioanalytical lab to offer rapid and sensitive drug concentration measurements with various indicators.

We offer DMPK studies including:

We offer DMPK Analysis:

• In Vivo PK

We offer comprehensive in vivo PK studies designed to provide a deep understanding of a drug's absorption, distribution, metabolism, and excretion within a living organism. Equipped with state-of-the-art facilities and an experienced research team, our laboratory precisely measures drug concentration changes in various tissues and fluids. Through our in vivo PK studies, you can obtain dynamic behavior data of the drug in the body, providing scientific support for drug development and optimization, ensuring drug safety and efficacy.

• Metabolite Identification

We are dedicated to uncovering the metabolic pathways and products of drugs within living organisms. Utilizing high-resolution mass spectrometry and multidimensional liquid chromatography techniques, we accurately identify and characterize the various metabolites produced during drug metabolism. Our expert team provides detailed structural information of metabolites and pathway analysis, helping you comprehensively understand the metabolic fate of the drug, predict potential metabolism-related toxicity risks, and offer crucial data support for drug design and improvement.

• Metabolite Profiling

We offer detailed metabolite profiling services to systematically analyze the distribution and changes of drugs and their metabolites within the body. Using advanced chromatography-mass spectrometry technologies, we perform highly sensitive and specific detection and quantification of metabolites in complex biological matrices. Our metabolite profiling service not only provides comprehensive metabolite spectra but also helps you understand the generation patterns of metabolites and their roles in the drug action process, thereby supporting your drug development and safety evaluation efforts.

• Drug Bioanalysis

Our specialized drug bioanalysis scientists provides high-quality data support for your drug research. By employing rigorously validated methods and high-performance analytical instruments, we accurately determine the concentrations of drugs and their metabolites in biological samples. Our bioanalysis service encompasses the entire process from sample preparation and analytical method development to data analysis, ensuring the accuracy and reliability of the data. Whether in early drug screening or clinical research phases, we provide timely and reliable bioanalysis data to facilitate the smooth progress of your drug development projects.

• LC-MS-based Bioanalysis

We provide LC-MS-based bioanalysis services, focusing on the highly sensitive and specific detection of drugs and metabolites. Our LC-MS bioanalysis service covers the entire process from method development and validation to sample analysis, ensuring accurate and reliable results. By employing cutting-edge LC-MS technology, we achieve detection and quantification of low-concentration drugs and metabolites in complex biological matrices, helping you gain a deep understanding of drug behavior and metabolic mechanisms in the body, providing a solid data foundation for your drug development.

The drug concentration-time profile data are modeled to determine PK parameters such as AUC, absorption, and elimination kinetics, t1/2, Cmax, Cmin, volume of distribution, and clearance rate using WinNonlin software (Pharsight Corporation, Mountain View, CA) or ADAPT-5 software (USC).

Carrying out the DMPK studies can establish dose range and administration schedule for subsequent clinical trials. Our team provides our clients with a smooth and seamless collaboration from drug candidates’ shipment to data processing. Also, our experts work closely with our clients to offer the integrated planning, implementation, feedback and guidance to advance their drug discovery projects about oncology immunotherapy.

Highlights

By outsourcing your DMPK studies to Creative Biolabs, we ensure:

• Comprehensive studies to cover all your needs,
• In industry-best timelines,
• Reproducible and accurate DMPK data and shaping outcomes.

Creative Biolabs is dedicated to the success of the candidates at the clinical stages regardless of unpredictable metabolic, pharmacokinetic or toxicity properties. Leveraging on our PK services will help you make informed decisions. Our scientists are dedicated to both discovery and development which can allow hit optimization to flow seamlessly into the development phase. Please contact us for further communications to learn how Creative Biolabs can be involved in your project.