Introduction to Anti-Peptide/Protein Antibody Discovery by Premade Antibody Library

Proteins, protein fragments, and peptides are the three main antigens used to generate antibodies. Therefore, anti-peptide antibodies are a powerful tool and are important in different research directions in biology. There are many avenues of functional antibody discovery, such as functional human antibodies, anti-cell-based target antibodies, bifunctional antibodies, and anti-epitope antibodies. Together, these different approaches have contributed to the development of antibodies. Based on our rich field experience and advanced research platform, Creative Biolabs provides comprehensive services to support premade antibody library screening and anti-peptide/protein antibody discovery.

Anti-peptide Antibody

An anti-peptide antibody is an antibody directed against a peptide antigen. Peptide antigens are composed of segments of natural protein sequences that are too short to be recognized by the immune system and produce corresponding antibodies. Peptide antigens can be prepared by chemical synthesis or genetic engineering techniques.

Anti-peptide antibodies have a wide range of applications. For example, they can be used to detect and quantify peptide molecules, including but not limited to drug metabolites, hormones, neuropeptides, cancer markers, etc. In addition, they can be used to study the structure and function of polypeptide molecules. In the clinic, anti peptide antibodies can be used to diagnose and treat many diseases, such as rheumatoid arthritis, systemic lupus erythematosus, scleroderma, autoimmune thyroid diseases, etc. Some scientists have also identified the potential of antipeptide antibodies in disease prediction, such as breast cancer prediction using anti-peptide antibodies.

Studies have demonstrated that citrulline is the major antigenic determinant cluster component recognized by anti-intermediate filament-associated protein-associated antibodies in patients with rheumatoid arthritis. Anti-cyclic citrullinated skin antibody is a multi-skinned fragment of cyclic polyfilament proteins, and it is an IgG-type dominant antibody. It has good sensitivity and specificity for rheumatoid arthritis and is a valuable diagnostic indicator for determining the course of rheumatoid arthritis. In addition, it has certain prognostic value. Meanwhile, clinical studies have shown that bone destruction in rheumatoid arthritis patients with positive anti-cyclic citrullinated skin antibodies is more serious than that in those with negative anti-cyclic citrullinated skin antibody.

Anti-protein Antibody

An anti-protein antibody is an antibody directed against protein antigens. Protein antigens are composed of specific regions in the native protein sequence. These areas can be the immune system to identify and produce antibodies.

Anti-protein antibodies have a wide range of applications. For example, they can be used for the qualitative and quantitative detection of protein molecules, including, but not limited to, drug metabolites, hormones, and biomarkers. They can also be used to study the structure and function of brain white matter molecules. In addition, clinically, anti-protein antibodies can be used for the diagnosis and treatment of diseases such as rheumatoid arthritis, systemic lupus erythematosus, scleroderma, and thyroid autoimmune diseases. Some scientists have also discovered the potential of anti-peptide antibodies in disease prediction, such as the use of anti-peptide antibodies to predict breast cancer.

Creative Biolabs has a wealth of knowledge and experience in premade antibody library screening. We would be happy to share with you our knowledge and experience in anti-peptide discovery and anti-protein antibody discovery by premade antibody library.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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