Introduction to pH-Sensitive Bioactive Peptide Discovery by Phage Display

Tumor tissues have special glycolytic metabolic processes, resulting in a weakly acidic tumor microenvironment, whereas normal tissue pH and blood pH are 7.4. Normal tissue pH and blood pH are both 7.4. Although the acidic environment of the tumor microenvironment promotes tumor development, the development of pH-sensitive biomolecules that take advantage of this property can lead to more specificity and targeting. Current pH-sensitive peptide drug delivery systems and pH-sensitive peptide drugs are precisely such pH-sensitive active peptides. And these pH-sensitive bioactive peptides have exerted remarkable activities. Based on our rich field experience and phage display platform, Creative Biolabs provides comprehensive services to support the development of pH-sensitive bioactive peptides.

Antibodies. (Creative Biolabs Authorized)

pH-sensitive Bioactive Peptides

pH-sensitive bioactive peptides play an important role in different directions of biomedical research, such as lytic peptides, drug delivery systems, and drug development. Especially in the field of oncology research, pH-sensitive active peptides offer new avenues for targeted tumor therapy.

Lytic peptides, a group of cationic peptides, primarily act on cell membranes, causing cell lysis. Studies on the interaction between lytic peptides and cells showed that the shift of peptides to the binding plane and their insertion into the membrane is key to the lytic peptide-induced cell membrane lysis. pH-controlled aggregation and solubilization are responsible for the peptide pH-dependent membrane lytic activity. We know that the extracellular pH of tumors is low. Therefore, peptides with acid-activating features have increased selectivity for cancer cells. This property allows pH-sensitive lytic peptides to have excellent activity in drug-sensitive and drug-resistant cells. Some pH-sensitive lytic peptides show up to a 30-fold increase in activity in media with reduced pH.

With the deeper understanding and study of peptides, scientists are gradually discovering the potential of cyclic peptides as anti-cancer agents. Cyclic peptides are polypeptide chain compounds containing cyclic bond sequences. They have good binding affinity, target selectivity, and low toxicity, which makes them an attractive therapeutic modality. We know that the tumor microenvironment is weakly acidic. In this case, pH-sensitive cyclic peptides play an obvious advantage in targeting tumor sites. pH-sensitive bioactive peptides are highly sensitive to the acidic environment. They affect the interactions between different residues of the peptide and produce conformational changes in the secondary structure through protonation or deprotonation of the side-chain motifs of the amino acid residues, thus reflecting their acid-responsiveness, which is conducive to the self-assembly or modification of pH-sensitive bioactive peptides by nanocarriers for targeting and releasing drugs or genes.

In the field of drug delivery, pH-sensitive oligopeptides play an important role in the field of targeted cancer therapy. They are highly sensitive to the acidic tumor microenvironment and can be efficiently eliminated from the body. The use of pH-sensitive oligopeptides as fluorescent probes for tumor diagnosis offers a safe and accurate approach. Furthermore, the fusion of pH-sensitive oligopeptides with cell-penetrating peptides holds promise in targeted delivery of antitumor drugs, especially in macromolecular therapies.

In summary, peptides owing to their inherent biological origin, possess excellent biocompatibility and degradability. They occupy a significant position in the field of nano drug delivery systems and disease treatment. Combined with the acidic tumor microenvironment, pH-sensitive bioactive peptides for antitumor drugs and drug delivery systems prove to be a highly effective research strategy.

More Details on Introduction to pH-sensitive Bioactive Peptide Discovery by Phage Display

Introduction to pH-Sensitive Lytic Peptide Discovery by Phage Display

Creative Biolabs has a wealth of knowledge and experience in pH-sensitive biomolecules. We would be happy to share with you our knowledge and experience in pH-sensitive bioactive peptide discovery.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

	USA: Europe: Germany:
	Call us at: USA: UK: Germany:
	Fax:
	Email: