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Magic™ Antibody Discovery - Cynomolgus/Rhesus macaque FcRn (FCGRT & B2M) (24-297(FCGRT)&21-119(B2M)) Membrane Protein, Partial, -His -Avi tag& -Strep II Tag, [Biotin] (CAT#: MP1437F)

Datasheet
This membrane protein is Cynomolgus/Rhesus macaque FcRn (FCGRT & B2M) (24-297(FCGRT)&21-119(B2M)). It has been tested in SDS-PAGE, SPR, BLI. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Cynomolgus / Rhesus macaque
  • Target Protein
  • FcRn (FCGRT & B2M)
  • Protein Length
  • ECD
  • Molecular Weight
  • Biotinylated Cynomolgus / Rhesus macaque FcRn Heterodimer Protein, His,Avitag&Strep II Tag (BLI verified), produced by co-expression of FCGRT and B2M, has a calculated MW of 34.1 kDa (FCGRT) and 13.0 kDa (B2M). Subunit FCGRT is fused with an Avi tag at the C-terminus, followed by a polyhistidine tag and subunit Beta-2 microglobulin (B2M) is fused with a Strep II tag at the C-terminus. The reducing (R) protein migrates as 40 kDa (FCGRT) and 14 kDa (B2M) respectively due to glycosylation.
  • Sequence
  • AA Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M) (Accession # Q8SPV9-1 (FCGRT) & Q8SPW0-1 (B2M)).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, SPR, BLI
  • Expression Systems
  • HEK293
  • Tag
  • Subunit FCGRT is fused with an Avi tag at the C-terminus, followed by a His tag and subunit Beta-2 microglobulin (B2M) is fused with a Strep II tag at the C-terminus.
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • FcRn (FCGRT & B2M)
  • Full Name
  • Fc fragment of IgG receptor and transporter&beta-2-microglobulin
  • Introduction
  • This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • FCRN, alpha-chain, IgG receptor FcRn large subunit p51, Fc fragment of IgG, receptor, transporter, alpha, FcRn alpha chain, IgG Fc fragment receptor transporter alpha chain, heavy chain of the major histocompatibility complex class I-like Fc receptor, immunoglobulin receptor, intestinal, heavy chain, major histocompatibility complex class I-like Fc receptor, neonatal Fc receptor, neonatal Fc-receptor for Ig, transmembrane alpha chain of the neonatal receptor

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