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Magic™ Antibody Discovery - Human COMP / TSP5 (21-757) Membrane Protein, Partial, -His tag (CAT#: MP1347F)

Datasheet
This membrane protein is Human COMP / TSP5 (21-757). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • COMP / TSP5
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 81.9 kDa. The protein migrates as 110-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Gln 21 - Ala 757 (Accession # AAI25093).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >88% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • COMP / TSP5
  • Full Name
  • cartilage oligomeric matrix protein
  • Introduction
  • The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
  • Alternative Names
  • MED; EDM1; EPD1; TSP5; PSACH; THBS5; cartilage oligomeric matrix protein; cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple); pseudoachondroplasia (epiphyseal dysplasia 1, multiple); thrombospondin-5

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