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Magic™ Antibody Discovery - Human EGFRvIII (25-378) Membrane Protein, Partial, -His tag (CAT#: MP0060F)

Datasheet
This membrane protein is Human EGFRvIII (25-378). It has been tested in SDS-PAGE, ELISA, SEC-HPLC. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • EGFRvIII
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 40.5 kDa. The protein migrates as 60-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Leu 25 - Ser 378 (Accession # NP_001333870.1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, SEC-HPLC
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
    >95% as determined by SEC-HPLC.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • EGFRvIII
  • Full Name
  • epidermal growth factor receptor
  • Introduction
  • The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-3).
  • Alternative Names
  • ERBB; HER1; mENA; ERBB1; PIG61; NISBD2;epidermal growth factor receptor;avian erythroblastic leukemia viral (v-erb-b) oncogene homolog;cell growth inhibiting protein 40;cell proliferation-inducing protein 61, epidermal growth factor receptor tyrosine kinase domain, erb-b2 receptor tyrosine kinase 1, proto-oncogene c-ErbB-1, receptor tyrosine-protein kinase erbB-1, EGFR, ERBB, ERBB1, HER1, PIG62, mENA

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