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Magic™ Antibody Discovery - Human GUCY2C / Guanylyl cyclase C (24-430) Membrane Protein, Partial, -hIgG1 Fc -Avi tag, [Biotin] (CAT#: MP0135F)

Datasheet
This membrane protein is Human GUCY2C / Guanylyl cyclase C (24-430). It has been tested in SDS-PAGE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GUCY2C / Guanylyl cyclase C
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 74.1 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Ser 24 - Gln 430 (Accession # P25092-1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus, followed by a Avi tag
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Conjugation
  • Biotin
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • GUCY2C / Guanylyl cyclase C
  • Full Name
  • guanylate cyclase 2C
  • Introduction
  • This gene encodes a transmembrane protein that functions as a receptor for endogenous peptides guanylin and uroguanylin, and the heat-stable E. coli enterotoxin. The encoded protein activates the cystic fibrosis transmembrane conductance regulator. Mutations in this gene are associated with familial diarrhea (autosomal dominant) and meconium ileus (autosomal recessive).
  • Alternative Names
  • GC-C; STAR; DIAR6; GUC2C; MECIL; MUCIL; heat-stable enterotoxin receptor; STA receptor; guanylyl cyclase C; intestinal guanylate cyclase

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