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Magic™ Antibody Discovery - Human Integrin alpha 10 beta 1 (23-1122(ITGA10)&21-728(ITGB1)) Membrane Protein, Partial, -His Tag & Tag free (CAT#: MP0334F)

Datasheet
This membrane protein is Human Integrin alpha 10 beta 1 (23-1122(ITGA10)&21-728(ITGB1)). It has been tested in SDS-PAGE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Integrin alpha 10 beta 1
  • Protein Length
  • ECD
  • Molecular Weight
  • Calculated MW of 126.6 kDa (ITGA10) and 83.7 kDa (ITGB1). The reducing (R) protein migrates as 140-160 kDa (ITGA10) and 100-130 kDa (ITGB1) respectively due to glycosylation.
  • Sequence
  • AA Phe 23 - Ser 1122 (ITGA10) & Gln 21 - Asp 728 (ITGB1) (Accession # O75578-1 (ITGA10) & P05556-1 (ITGB1)).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA
  • Expression Systems
  • HEK293
  • Tag
  • ITGA10 is fused with an acidic tail at the C-terminus. and followed by His tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus.
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Integrin alpha 10 beta 1
  • Full Name
  • integrin subunit alpha 10&integrin subunit beta 1
  • Introduction
  • Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to collagen. Alternative splicing results in multiple transcript variants.&Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
  • Alternative Names
  • Integrin alpha 10 beta 1, ITGA10&ITGB1

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