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Magic™ Antibody Discovery - Human TSLP (29-159) Membrane Protein, Partial, -His -Avi tag, [Biotin] (CAT#: MP0424F)

Datasheet
This membrane protein is Human TSLP (29-159). It has been tested in SDS-PAGE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • TSLP
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 18.6 kDa. As a result of glycosylation, the protein migrates as 11 kDa and 18-21 kDa under reducing (R) condition, and 22-28 kDa under non-reducing (NR) condition (SDS-PAGE).
  • Sequence
  • AA Tyr 29 - Gln 159 (Accession # Q969D9-1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus, followed by an Avi tag.
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Conjugation
  • Biotin
  • Purity
  • >85% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • TSLP
  • Full Name
  • thymic stromal lymphopoietin
  • Introduction
  • This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. In addition, the shorter (predominant) isoform is an antimicrobial protein, displaying antibacterial and antifungal activity against B. cereus, E. coli, E. faecalis, S. mitis, S. epidermidis, and C. albicans. Alternative splicing of this gene results in multiple transcript variants.
  • Alternative Names
  • TSLP, thymic stromal lymphopoietin,

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