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Magic™ Antibody Discovery - Mouse TNF-alpha (80-235) Membrane Protein, Partial, -His -Avi tag, [Biotin] (CAT#: MP0493F)

Datasheet
This membrane protein is Mouse TNF-alpha (80-235). It has been tested in SDS-PAGE, ELISA, SEC-MALS. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Mouse
  • Target Protein
  • TNF-alpha
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 20.2 kDa. The protein migrates as 21 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Leu 80 - Leu 235 (Accession # P06804).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, SEC-MALS
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus, followed by an Avi tag.
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by reduced SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • TNF-alpha
  • Full Name
  • tumor necrosis factor
  • Introduction
  • This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure. This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions. It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation. In mouse deficiency of this gene is associated with defects in response to bacterial infection, with defects in forming organized follicular dendritic cell networks and germinal centers, and with a lack of primary B cell follicles. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • DI; Tn; DIF; TNF-; Tnfa; Tnfs; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha; tumor necrosis factor; cachectin; tumor necrosis factor ligand 1f; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha

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