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Magic™ Membrane Protein Human ACVR2A (Activin A receptor type 2A) Expressed in CHO for Antibody Discovery, Partial (1-134aa) (CAT#: MPX0187K)

Datasheet
This product is a 40 kDa Human ACVR2A membrane protein expressed in CHO. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ACVR2A
  • Protein Length
  • Partial (1-134aa)
  • Protein Class
  • Transferase
  • Molecular Weight
  • 40 kDa
  • TMD
  • 1
  • Sequence
  • MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPC
    YGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEV
    YFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKP

Product Description

  • Expression Systems
  • CHO
  • Tag
  • hIgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in PBS.
  • Endotoxin
  • <0.01 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • ACVR2A
  • Full Name
  • Activin A receptor type 2A
  • Introduction
  • This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.
  • Alternative Names
  • ACVR2A; ACVR2; ACTRII; activin receptor type-2A; activin A receptor, type IIA; Activin A receptor type 2A
  • Gene ID
  • 92

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