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Magic™ Membrane Protein Human ASGR2 (Asialoglycoprotein receptor 2) Expressed in CHO for Antibody Discovery, Partial (80-311aa) (CAT#: MPX0506K)

Datasheet
This product is a 53 kDa Human ASGR2 membrane protein expressed in CHO. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ASGR2
  • Protein Length
  • Partial (80-311aa)
  • Protein Class
  • Receptor
  • Molecular Weight
  • 53 kDa
  • TMD
  • 1
  • Sequence
  • QSEGHGGAQLQAELRSLKEAF
    SNFSSSTLTEVQAISTHGGSVGDKITSLGAKLEKQQQDLKADHDALLFHL
    KHFPVDLRFVACQMELLHSNGSQRTCCPVNWVEHQGSCYWFSHSGKAWAE
    AEKYCQLENAHLVVINSWEEQKFIVQHTNPFNTWIGLTDSDGSWKWVDGT
    DYRHNYKNWAVTQPDNWHGHELGGSEDCVEVQPDGRWNDDFCLQVYRWVC
    EKRRNATGEVA

Product Description

  • Activity
  • Yes
  • Expression Systems
  • CHO
  • Tag
  • hIgG1 Fc tag at the N-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 500 μg/mL in PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • ASGR2
  • Full Name
  • Asialoglycoprotein receptor 2
  • Introduction
  • This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
  • Alternative Names
  • ASGR2; HL-2; HBXBP; ASGPR2; ASGP-R2; CLEC4H2; C-type lectin domain family 4 member H2; HBxAg-binding protein; hepatic lectin H2; Asialoglycoprotein receptor 2

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