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Magic™ Membrane Protein Human ATP2B4 (ATPase plasma membrane Ca2+ transporting 4) Full Length (CAT#: MPC1153K) Made to Order

Datasheet
This product is a 137.9 kDa Human ATP2B4 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ATP2B4
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 137.9 kDa
  • TMD
  • 10
  • Sequence
  • MTNPSDRVLPANSMAESREGDFGCTVMELRKLMELRSRDALTQINVHYGG
    VQNLCSRLKTSPVEGLSGNPADLEKRRQVFGHNVIPPKKPKTFLELVWEA
    LQDVTLIILEIAAIISLVLSFYRPAGEENELCGQVATTPEDENEAQAGWI
    EGAAILFSVIIVVLVTAFNDWSKEKQFRGLQCRIEQEQKFSIIRNGQLIQ
    LPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSL
    DKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIILTLLGVNEDDEGEKKKK
    GKKQGVPENRNKAKTQDGVALEIQPLNSQEGIDNEEKDKKAVKVPKKEKS
    VLQGKLTRLAVQIGKAGLLMSALTVFILILYFVIDNFVINRRPWLPECTP
    IYIQYFVKFFIIGITVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHL
    DACETMGNATAICSDKTGTLTMNRMTVVQAYIGGIHYRQIPSPDVFLPKV
    LDLIVNGISINSAYTSKILPPEKEGGLPRQVGNKTECALLGFVTDLKQDY
    QAVRNEVPEEKLYKVYTFNSVRKSMSTVIRNPNGGFRMYSKGASEIILRK
    CNRILDRKGEAVPFKNKDRDDMVRTVIEPMACDGLRTICIAYRDFDDTEP
    SWDNENEILTELTCIAVVGIEDPVRPEVPDAIAKCKQAGITVRMVTGDNI
    NTARAIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKIWPKL
    RVLARSSPTDKHTLVKGIIDSTVGEHRQVVAVTGDGTNDGPALKKADVGF
    AMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTV
    NVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLL
    KRRPYGRNKPLISRTMMKNILGHAFYQLIVIFILVFAGEKFFDIDSGRKA
    PLHSPPSQHYTIVFNTFVLMQLFNEINSRKIHGEKNVFSGIYRNIIFCSV
    VLGTFICQIFIVEFGGKPFSCTSLSLSQWLWCLFIGIGELLWGQFISAIP
    TRSLKFLKEAGHGTTKEEITKDAEGLDEIDHAEMELRRGQILWFRGLNRI
    QTQIDVINTFQTGASFKGVLRRQNMGQHLDVKLVPSSSYIKVVKAFHSSL
    HESIQKPYNQKSIHSFMTHPEFAIEEELPRTPLLDEEEEENPDKASKFGT
    RVLLLDGEVTPYANTNNNAVDCNQVQLPQSDSSLQSLETSV

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • ATP2B4
  • Full Name
  • ATPase plasma membrane Ca2+ transporting 4
  • Introduction
  • The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Alternative Names
  • ATP2B4; MXRA1; PMCA4; ATP2B2; PMCA4b; PMCA4x; plasma membrane calcium-transporting ATPase 4; ATPase, Ca++ transporting, plasma membrane 4; matrix-remodeling-associated protein 1; sarcolemmal calcium pump; ATPase plasma membrane Ca2+ transporting 4

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