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Magic™ Membrane Protein Human CLCN7 (Chloride voltage-gated channel 7) Full Length (CAT#: MPC0486K) Made to Order

Datasheet
This product is a 88.6 kDa Human CLCN7 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CLCN7
  • Protein Length
  • Full length
  • Protein Class
  • Transporter; Ion channel
  • Molecular Weight
  • 88.6 kDa
  • TMD
  • 15
  • Sequence
  • MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPR
    SALFRVGHMSSVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYD
    NSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVEN
    LAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPV
    AAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPM
    IHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA
    FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMW
    DLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLT
    MFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPL
    QLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFL
    ACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALM
    GAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG
    LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDV
    LSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLG
    LVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQ
    EASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEEL
    SLAQT

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • CLCN7
  • Full Name
  • Chloride voltage-gated channel 7
  • Introduction
  • The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood.
  • Alternative Names
  • HOD; CLC7; CLC-7; OPTA2; OPTB4; PPP1R63; H(+)/Cl(-) exchange transporter 7; chloride channel 7 alpha subunit; chloride channel protein 7; chloride channel, voltage-sensitive 7; protein phosphatase 1, regulatory subunit 63; CLCN7; Chloride voltage-gated channel 7

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