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Magic™ Membrane Protein Human FZD6 (Frizzled class receptor 6) Full Length (CAT#: MPC0101K) Made to Order

Datasheet
This product is a 79.2 kDa Human FZD6 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • FZD6
  • Protein Length
  • Full length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 79.2 kDa
  • TMD
  • 7
  • Sequence
  • MEMFTFLLTCIFLPLLRGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYD
    QSIAAVEMEHFLPLANLECSPNIETFLCKAFVPTCIEQIHVVPPCRKLCE
    KVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPVTFDPHTEFLGPQKKT
    EQVQRDIGFWCPRHLKTSGGQGYKFLGIDQCAPPCPNMYFKSDELEFAKS
    FIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFI
    GFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWW
    VILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEG
    DNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVI
    QHDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWV
    SDHCRQYHIPCPYQAKAKARPELALFMIKYLMTLIVGISAVFWVGSKKTC
    TEWAGFFKRNRKRDPISESRRVLQESCEFFLKHNSKVKHKKKHYKPSSHK
    LKVISKSMGTSTGATANHGTSAVAITSHDYLGQETLTEIQTSPETSMREV
    KADGASTPRLREQDCGEPASPAASISRLSGEQVDGKGQAGSVSESARSEG
    RISPKSDITDTGLAQSNNLQVPSSSEPSSLKGSTSLLVHPVSGVRKEQGG
    GCHSDT

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • FZD6
  • Full Name
  • Frizzled class receptor 6
  • Introduction
  • This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.
  • Alternative Names
  • FZ6; FZ-6; HFZ6; NDNC1; NDNC10; frizzled-6; frizzled 6, seven transmembrane spanning receptor; frizzled family receptor 6; frizzled homolog 6; seven transmembrane helix receptor; FZD6; Frizzled class receptor 6

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