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Magic™ Membrane Protein Human GNRHR (Gonadotropin releasing hormone receptor) Full Length (CAT#: MPC0113K) Made to Order

Datasheet
This product is a 37.7 kDa Human GNRHR membrane protein expressed in Baculovirus/Insect expression system. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GNRHR
  • Protein Length
  • Full length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 37.7 kDa
  • TMD
  • 7
  • Sequence
  • MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSA
    TFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGM
    WNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALK
    SNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHC
    SFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQ
    LNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
    SDPVNHFFFLFAFLNPCFDPLIYGYFSL

Product Description

  • Expression Systems
  • Baculovirus/Insect expression system
  • Tag
  • Flag tag at N-terminal and 10xHis tag at C-terminal
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • GNRHR
  • Full Name
  • Gonadotropin releasing hormone receptor
  • Introduction
  • This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.
  • Alternative Names
  • HH7; GRHR; LRHR; LHRHR; GNRHR1; gonadotropin-releasing hormone receptor; gnRH receptor; gnRH-R; gonadotropin-releasing hormone (type 1) receptor 1; leutinizing hormone releasing horomone receptor; leutinizing-releasing hormone receptor; luliberin receptor; type I GnRH receptor; GNRHR; Gonadotropin releasing hormone receptor

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