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Magic™ Membrane Protein Human GP1BB (Glycoprotein Ib platelet subunit beta) Full Length (CAT#: MPC1827K) Made to Order

Datasheet
This product is a 21.7 kDa Human GP1BB membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GP1BB
  • Protein Length
  • Full length
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 21.7 kDa
  • TMD
  • 1
  • Sequence
  • MGSGPRGALSLLLLLLAPPSRPAAGCPAPCSCAGTLVDCGRRGLTWASLP
    TAFPVDTTELVLTGNNLTALPPGLLDALPALRTAHLGANPWRCDCRLVPL
    RAWLAGRPERAPYRDLRCVAPPALRGRLLPYLAEDELRAACAPGPLCWGA
    LAAQLALLGLGLLHALLLVLLLCRLRRLRARARARAAARLSLTDPLVAER
    AGTDES

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • GP1BB
  • Full Name
  • Glycoprotein Ib platelet subunit beta
  • Introduction
  • Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene.
  • Alternative Names
  • GP1BB; BS; CD42C; GPIBB; BDPLT1; GPIbbeta; platelet glycoprotein Ib beta chain; GP-Ib beta; antigen CD42b-beta; glycoprotein Ib (platelet), beta polypeptide; glycoprotein Ib platelet beta subunit; nuclear localization signal deleted in velocardiofacial syndrome; platelet membrane glycoprotein Ib beta; truncated platelet membrane glycoprotein Ib beta; Glycoprotein Ib platelet subunit beta

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