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Magic™ Membrane Protein Human INSIG1 (Insulin induced gene 1) Full Length (CAT#: MPC2959K) Made to Order

This product is a made-to-order Human INSIG1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • INSIG1
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • TMD
  • 6
  • Sequence
  • MPRLHDHFWSCSCAHSARRRGPPRASAAGLAAKVGEMINVSVSGPSLLAA
    HGAPDADPAPRGRSAAMSGPEPGSPYPNTWHHRLLQRSLVLFSVGVVLAL
    VLNLLQIQRNVTLFPEEVIATIFSSAWWVPPCCGTAAAVVGLLYPCIDSH
    LGEPHKFKREWASVMRCIAVFVGINHASAKLDFANNVQLSLTLAALSLGL
    WWTFDRSRSGLGLGITIAFLATLITQFLVYNGVYQYTSPDFLYIRSWLPC
    IFFSGGVTVGNIGRQLAMGVPEKPHSD

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • INSIG1
  • Full Name
  • Insulin induced gene 1
  • Introduction
  • This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • INSIG1; CL6; insulin-induced gene 1 protein; INSIG-1 membrane protein; Insulin induced gene 1

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