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Magic™ Membrane Protein Human KCNA5 (Potassium voltage-gated channel subfamily A member 5) Full Length (CAT#: MPC0581K) Made to Order

Datasheet
This product is a 67.2 kDa Human KCNA5 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • KCNA5
  • Protein Length
  • Full length
  • Protein Class
  • Transporter; Ion channel
  • Molecular Weight
  • 67.2 kDa
  • TMD
  • 6
  • Sequence
  • MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPA
    PKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEG
    DPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPA
    KRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEI
    RFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSAR
    AIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANG
    SGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKA
    GFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILR
    VIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSS
    AVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLC
    AIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDR
    GVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSL
    YALCLDTSRETDL

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • KCNA5
  • Full Name
  • Potassium voltage-gated channel subfamily A member 5
  • Introduction
  • Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7).
  • Alternative Names
  • HK2; HCK1; PCN1; ATFB7; HPCN1; KV1.5; potassium voltage-gated channel subfamily A member 5; cardiac potassium channel; insulinoma and islet potassium channel; potassium channel 1; potassium channel, voltage gated shaker related subfamily A, member 5; potassium voltage-gated channel, shaker-related subfamily, member 5; voltage-gated potassium channel HK2; voltage-gated potassium channel protein Kv1.5; voltage-gated potassium channel subunit Kv1.5; KCNA5; Potassium voltage-gated channel subfamily A member 5

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