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Magic™ Membrane Protein Human KCNJ1 (Potassium inwardly rectifying channel subfamily J member 1) Full Length (CAT#: MPC0601K) Made to Order

Datasheet
This product is a 44.7 kDa Human KCNJ1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • KCNJ1
  • Protein Length
  • Full length
  • Protein Class
  • Transporter; Ion channel
  • Molecular Weight
  • 44.7 kDa
  • TMD
  • 2
  • Sequence
  • MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCN
    IEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWY
    AVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVT
    EQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVI
    SKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININ
    FVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
    VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEV
    ETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • KCNJ1
  • Full Name
  • Potassium inwardly rectifying channel subfamily J member 1
  • Introduction
  • Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • ROMK; ROMK1; KIR1.1; ATP-sensitive inward rectifier potassium channel 1; ATP-regulated potassium channel ROM-K; inward rectifier K(+) channel Kir1.1; inwardly rectifying K+ channel; potassium channel, inwardly rectifying subfamily J member 1; potassium voltage-gated channel subfamily J member 1; KCNJ1; Potassium inwardly rectifying channel subfamily J member 1

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