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Magic™ Membrane Protein Human KCNN1 (Potassium calcium-activated channel subfamily N member 1) Full Length (CAT#: MPC1045K) Made to Order

Datasheet
This product is a 59.9 kDa Human KCNN1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • KCNN1
  • Protein Length
  • Full length
  • Protein Class
  • Transporter; Ion channel
  • Molecular Weight
  • 59.9 kDa
  • TMD
  • 6
  • Sequence
  • MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSE
    PARPSPGSPRGQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALF
    EKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLYSFALKCLISLST
    AILLGLVVLYHAREIQLFMVDNGADDWRIAMTCERVFLISLELAVCAIHP
    VPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYLLGRVMLLHSK
    IFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWT
    VRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLT
    GIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLR
    ETWLIYKHTRLVKKPDQARVRKHQRKFLQAIHQAQKLRSVKIEQGKLNDQ
    ANTLTDLAKTQTVMYDLVSELHAQHEELEARLATLESRLDALGASLQALP
    GLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPSDCG

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • KCNN1
  • Full Name
  • Potassium calcium-activated channel subfamily N member 1
  • Introduction
  • Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes.
  • Alternative Names
  • KCNN1; SK1; hSK1; SKCA1; KCa2.1; small conductance calcium-activated potassium channel protein 1; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1; small conductance calcium-activated potassium channel 1; SK; Potassium calcium-activated channel subfamily N member 1

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