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Magic™ Membrane Protein Human NFASC (Neurofascin) Expressed in E.coli with 6xHis tag at the N-terminus for Antibody Discovery, Partial (1239-1347aa) (CAT#: MPX4496K)

Datasheet
This product is a 15.9kDa Human NFASC membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • NFASC
  • Protein Length
  • Partial (1239-1347aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 15.9kDa
  • TMD
  • 1
  • Sequence
  • KRSRGGKYPVREKKDVPLGPEDPKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA

Product Description

  • Expression Systems
  • E.coli
  • Tag
  • 6xHis tag at the N-terminus
  • Protein Format
  • Soluble
  • Purity
  • >90% as determined by SDS-PAGE
  • Buffer
  • Tris-based buffer, 50% glycerol

Target

  • Target Protein
  • NFASC
  • Full Name
  • Neurofascin
  • Introduction
  • This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.
  • Alternative Names
  • NFASC; NF; NRCAML; NEDCPMD; neurofascin; neurofascin homolog; Neurofascin

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