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Magic™ Membrane Protein Human NPC1 (NPC intracellular cholesterol transporter 1) Expressed in Yeast with 6xHis and Myc tag at the C-terminus for Antibody Discovery, Partial (23-261aa) (CAT#: MPX4168K)

Datasheet
This product is a 30.2 kDa Human NPC1 membrane protein expressed in Yeast. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • NPC1
  • Protein Length
  • Partial (23-261aa)
  • Protein Class
  • Transporter
  • Molecular Weight
  • 30.2 kDa
  • TMD
  • 13
  • Sequence
  • QSCVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWT

Product Description

  • Expression Systems
  • Yeast
  • Tag
  • 6xHis and Myc tag at the C-terminus
  • Protein Format
  • Soluble
  • Purity
  • >90% as determined by SDS-PAGE
  • Buffer
  • Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Target

  • Target Protein
  • NPC1
  • Full Name
  • NPC intracellular cholesterol transporter 1
  • Introduction
  • This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.
  • Alternative Names
  • NPC1; NPC; POGZ; SLC65A1; Niemann-Pick C1 protein; truncated Niemann-Pick C1; NPC intracellular cholesterol transporter 1

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