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Magic™ Membrane Protein Human SLC5A7 (Solute carrier family 5 member 7) Full Length (CAT#: MPC0886K) Made to Order

Datasheet
This product is a 63.2 kDa Human SLC5A7 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SLC5A7
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 63.2 kDa
  • TMD
  • 13
  • Sequence
  • MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIG
    LLVGGFTMTATWVGGGYINGTAEAVYVPGYGLAWAQAPIGYSLSLILGGL
    FFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALG
    ATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLW
    ISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLMLG
    GIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDW
    NQTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADS
    SILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTK
    TVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGG
    EPYLYLQPLIFYPGYYPDDNGIYNQKFPFKTLAMVTSFLTNICISYLAKY
    LFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLDELALVKPRQS
    MTLSSTFTNKEAFLDVDSSPEGSGTEDNLQ

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • SLC5A7
  • Full Name
  • Solute carrier family 5 member 7
  • Introduction
  • This gene encodes a sodium ion- and chloride ion-dependent high-affinity transporter that mediates choline uptake for acetylcholine synthesis in cholinergic neurons. The protein transports choline from the extracellular space into presynaptic terminals for synthesis into acetylcholine. Increased choline uptake results from increased density of this protein in synaptosomal plasma membranes in response to depolarization of cholinergic terminals. Dysfunction of cholinergic signaling has been implicated in various disorders including depression, attention-deficit disorder, and schizophrenia. An allelic variant of this gene is associated with autosomal dominant distal hereditary motor neuronopathy type VIIA. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • CHT; CHT1; CMS20; HMN7A; high affinity choline transporter 1; high affinity choline transporter; hemicholinium-3-sensitive choline transporter; solute carrier family 5 (sodium/choline cotransporter), member 7; SLC5A7; Solute carrier family 5 member 7

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