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Magic™ Membrane Protein Human SYNE4 (Spectrin repeat containing nuclear envelope family member 4) Full Length (CAT#: MPC3106K) Made to Order

Datasheet
This product is a made-to-order Human SYNE4 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SYNE4
  • Protein Length
  • Full length
  • Protein Class
  • Receptor
  • TMD
  • 1
  • Sequence
  • MALSLPLGPRLGSEPLNHPPGAPREADIVGCTVCPASGEESTSPEQAQTL
    GQDSLGPPEHFQGGPRGNEPAAHPPRWSTPSSYEDPAGGKHCEHPISGLE
    VLEAEQNSLHLCLLGLGRRLQDLEQGLGHWALAQSGMVQLQALQVDLRGA
    AERVEALLAFGEGLAQRSEPRAWAALEQILRALGAYRDSIFRRLWQLQAQ
    LVSYSLVFEEANTLDQDLEVEGDSDWPGPGGVWGPWAPSSLPTSTELEWD
    PAGDIGGLGPLGQKTARTLGVPCELCGQRGPQGRGQGLEEADTSHSRQDM
    LESGLGHQKRLARHQRHSLLRKPQDKKRQASPHLQDVRLEGNPGAPDPAS
    RQPLTFLLILFLLFLLLVGAMFLLPASGGPCCSHARIPRTPYLVLSYVNG
    LPPV

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • SYNE4
  • Full Name
  • Spectrin repeat containing nuclear envelope family member 4
  • Introduction
  • This gene is a member of the nesprin family of genes, that encode KASH (Klarsicht, Anc-1, Syne Homology) domain-containing proteins. In addition to the KASH domain, this protein also contains a coiled-coil and leucine zipper region, a spectrin repeat, and a kinesin-1 binding region. This protein localizes to the outer nuclear membrane, and is part of the linker of nucleoskeleton and cytoskeleton (LINC) complex in the nuclear envelope. LINC complexes are formed by SUN (Sad1, UNC-84)-KASH pairs, and are thought to mechanically couple nuclear components to the cytoskeleton. Mutations in this gene have been associated with progressive high-frequency hearing loss. The absence of this protein in mice also caused hearing loss, and changes in hair cell morphology in the ears. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Alternative Names
  • SYNE4; KASH4; Nesp4; DFNB76; C19orf46; nesprin-4; KASH domain-containing protein 4; deafness, autosomal recessive 76; nuclear envelope spectrin repeat protein 4; Spectrin repeat containing nuclear envelope family member 4

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