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Magic™ Membrane Protein Human TMEM43 (Transmembrane protein 43) Full Length (CAT#: MPC1300K) Made to Order

This product is a 44.8 kDa Human TMEM43 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • TMEM43
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 44.8 kDa
  • TMD
  • 4
  • Sequence
  • MAANYSSTSTRREHVKVKTSSQPGFLERLSETSGGMFVGLMAFLLSFYLI
    FTNEGRALKTATSLAEGLSLVVSPDSIHSVAPENEGRLVHIIGALRTSKL
    LSDPNYGVHLPAVKLRRHVEMYQWVETEESREYTEDGQVKKETRYSYNTE
    WRSEIINSKNFDREIGHKNPSAMAVESFMATAPFVQIGRFFLSSGLIDKV
    DNFKSLSLSKLEDPHVDIIRRGDFFYHSENPKYPEVGDLRVSFSYAGLSG
    DDPDLGPAHVVTVIARQRGDQLVPFSTKSGDTLLLLHHGDFSAEEVFHRE
    LRSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKA
    FAFCVATSLTLLTVAAGWLFYRPLWALLIAGLALVPILVARTRVPAKKLE

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • TMEM43
  • Full Name
  • Transmembrane protein 43
  • Introduction
  • This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC.
  • Alternative Names
  • TMEM43; LUMA; ARVC5; ARVD5; EDMD7; UNQ2564/PRO6244; Transmembrane protein 43

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