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Magic™ Membrane Protein Human TNFRSF13C (TNF receptor superfamily member 13C) Expressed in NS0 for Antibody Discovery, Partial (7-71aa) (CAT#: MPX0130K)

Datasheet
This product is a 33 kDa Human TNFRSF13C membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • TNFRSF13C
  • Protein Length
  • Partial (7-71aa)
  • Protein Class
  • Receptor; Immunity
  • Molecular Weight
  • 33 kDa
  • TMD
  • 1
  • Sequence
  • SLRGRDAPAPTPCVPAECFDLLVRHCVACGLLRTPRPKPAGASS
    PAPRTALQPQESVGAGAGEAA

Product Description

  • Expression Systems
  • NS0
  • Tag
  • hIgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <1.0 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • TNFRSF13C
  • Full Name
  • TNF receptor superfamily member 13C
  • Introduction
  • B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
  • Alternative Names
  • TNFRSF13C; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin; tumor necrosis factor receptor superfamily member 13C; B cell-activating factor receptor; BAFF receptor; BLyS receptor 3; TNF receptor superfamily member 13C

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