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NativeExtract™ Human ADGRB1 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX320)

Datasheet
This product is recombinant Human ADGRB1 protein in native nanodisc form. The synthetic compound we developed can solubilize the ADGRB1 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ADGRB1
  • Protein Length
  • Full length
  • Molecular Weight
  • 173.5kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • ADGRB1
  • Full Name
  • Adhesion G protein-coupled receptor B1
  • Introduction
  • Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.
  • Alternative Names
  • BAI1; GDAIF; brain-specific angiogenesis inhibitor 1; ADGRB1; Adhesion G protein-coupled receptor B1

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