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NativeExtract™ Human NPC1L1 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX405)

Datasheet
This product is recombinant Human NPC1L1 protein in native nanodisc form. The synthetic compound we developed can solubilize the NPC1L1 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • NPC1L1
  • Protein Length
  • Full length
  • Molecular Weight
  • 148.7 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • NPC1L1
  • Full Name
  • NPC1 like intracellular cholesterol transporter 1
  • Introduction
  • The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • NPC1L1; LDLCQ7; NPC11L1; SLC65A2; NPC1-like intracellular cholesterol transporter 1; NPC1 (Niemann-Pick disease, type C1, gene)-like 1; NPC1 like 1; niemann-Pick C1-like protein 1; NPC1 like intracellular cholesterol transporter 1

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