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NativeExtract™ Human OPRK1 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX130)

Datasheet
This product is recombinant Human OPRK1 protein in native nanodisc form. The synthetic compound we developed can solubilize the OPRK1 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • OPRK1
  • Protein Length
  • Full length
  • Molecular Weight
  • 42.6kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • OPRK1
  • Full Name
  • Opioid receptor kappa 1
  • Introduction
  • This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
  • Alternative Names
  • KOP; KOR; KOR1; OPRK; KOR-1; K-OR-1; kappa-type opioid receptor; Opiate receptor, kappa-1; kappa opioid receptor; OPRK1; Opioid receptor kappa 1

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