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EDN1

ET-1 is the most potent member of the ET family, which consists of the isopeptides ET-1, ET-2, and ET-3. The primary translation product of the ET-1 gene, prepro-ET-1 (212 amino acids), is cleaved by an intracellular endopeptidase releasing big ET-1 (38 amino acids). The biologically inactive big ET-1 is secreted primarily by endothelial cells and undergoes further processing by ET-converting enzymes (ECEs).

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