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TTR

Transthyretin (TTR, Prealbumin) is synthesized by the liver as a 127 amino acid non-glycosylated polypeptide chain. The entity, circulating in plasma, is a structurally stable tetramer composed of four identical monomers. It was originally called pre-albumin, however it has no structural relationship with albumin. The main function of transthyretin is transport of thyroxin and retinol binding protein i.e. vitamin A. The transthyretin concentration in plasma ranges from 20-40 mg/ml and the level is decreased in subjects suffering from malnutrition or chronic inflammation. In hereditary transthyretin amyloidosis, mutated transthyretin causes aggregation and formation of amyloid deposits in tissues with peripheral neuropathy as the major clinical manifestation.

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