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Adeno-associated Virus-Like Particles (AAV VLPs) (CAT#: VLP-034YF)

Datasheet
Recombinant Adeno-associated Virus-Like Particles (AAV VLPs) are produced in insect cells with capsid protein VP1, VP2 and VP3. VLP is mimicking the native 3D structure of viruses which can elicit strong immune responses. However, VLPs lack viral genomic material which makes them non-infectious, unable to replicate and enhance the safety during manufacture and administration. AAV VLPs can be used in the development of AAV diagnostics and in vaccine development and R&D (including use as an immunogen).

Product Specifications

  • Structural Proteins
  • Capsid protein VP1, VP2 and VP3
  • Expression Systems
  • HEK293 expression system
  • Form
  • Liquid
  • Alternative Names
  • Adeno-associated virus-like particles; AAV VLPs; Adeno-associated virus; AAV virus-like particles; VLPs; Virus-like Particles
  • Storage
  • Store at 4°C short term (2-4 weeks). Store at -80 °C long term. Avoid repeated freeze/thaw cycles.

Virus Background

  • Virus Family
  • Parvoviridae
  • Virus Species
  • Adeno-associated Virus
  • Virus Overview
  • Adeno-associated viruses (AAV) are small viruses that infect humans and some other primate species. They belong to the genus Dependoparvovirus, which in turn belongs to the family Parvoviridae. They are small (20 nm) replication-defective, nonenveloped viruses and have linear single-stranded DNA (ssDNA) genome of approximately 4.8 kilobases (kb).AAV are not currently known to cause disease. The viruses cause a very mild immune response. Several additional features make AAV an attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell, although in the native virus integration of virally carried genes into the host genome does occur. Integration can be important for certain applications, but can also have unwanted consequences. Recent human clinical trials using AAV for gene therapy in the retina have shown promise.
  • Virus Structure
  • Non-enveloped, single-stranded linear DNA

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