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- Anti-CD70 (clone 1F6-C4v2)-Mc-VC-MMAF ADC
Anti-CD70 (clone 1F6-C4v2)-Mc-VC-MMAF ADC (CAT#: ADC-W-364)
This ADC product is comprised of an anti-CD70 monoclonal antibody (clone 1F6-C4v2) conjugated via a Mc-vc linker to a MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Antibody clone #
- h1F6-C4v2
- Name
- CD70
- Alternative Names
- CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7;
- Target Entrez Gene ID
- 970
- Target UniProt ID
- P32970
- Overview
- The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
- Overview
- Humanized Anti-CD70 lgG1 Antibody, clone # h1F6-C4v2
- Clone #
- h1F6-C4v2
- Species Reactivity
- Human
- Name
- mc-VC (maleimidocaproyl-valine-citrulline)
- Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Name
- MMAF (Monomethyl auristatin F)
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
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Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-950 | Anti-CD70 (Vorsetuzumab)-SMCC-DM1 ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-567 | Anti-CD70-DM1 ADC | Noncleavable thioether linker | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-471 | Anti-CD70-VC-MED-2460-ADC | VC (valine-citrulline) | MED-2460 |
| ADC-W-376 | Anti-CD70 (clone h1F6)-β-glucuronide-doxorubicin ADC | β-glucuronide linker | doxorubicin |
| ADC-W-587 | Anti-CD70 (clone h1F6 )-Mc-VC-PABC-MMAE ADC | MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE (Monomethyl auristatin E) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-343 | Anti-TNFRSF8 (cAC10)-Mc-VC-MMAE ADC | mc-VC (maleimidocaproyl-valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-446 | Anti-CD70 (clone h1F6)-Mc-VC-PBD ADC | mc-VC (maleimidocaproyl-valine-citrulline) | pyrrolobenzodiazepine (PBD) dimers |
| ADC-W-430 | Anti-PMEL (clone 31D1.6.7)-Mc-VC-MMAE ADC | mc-VC (maleimidocaproyl-valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-432 | Anti-FOLH1 (MLN591)-Mc-VC-MMAE ADC | mc-VC (maleimidocaproyl-valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-435 | Anti-SLITRK6 (clone AGS15)-Mc-VC-MMAE ADC | mc-VC (maleimidocaproyl-valine-citrulline) | MMAE (Monomethyl auristatin E) |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-019 | anti-MIgG(Fc)-N-MMAF ADC | Noncleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-W-515 | Anti-EGFR (ABT-806)-Mc-MMAF ADC | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-AA-028 | anti-MIgG(Fc)Fab-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-W-537 | Anti-TPBG-Mc-MMAF ADC | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-AA-002 | anti-HIgG(Fc)-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
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