- Home
- Products
- Customized ADCs
- CD70
- Anti-CD70 (clone 1F6)-VC-MMAF ADC
Anti-CD70 (clone 1F6)-VC-MMAF ADC (CAT#: ADC-W-082)
This ADC product is comprised of an anti-CD70 monoclonal antibody (clone 1F6) conjugated via a VC linker to MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Antibody clone #
- 1F6
- Name
- CD70
- Alternative Names
- CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7;
- Target Entrez Gene ID
- 970
- Target UniProt ID
- P32970
- Overview
- The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
- Overview
- Anti-CD70 antibody, clone # 1F6
- Clone #
- 1F6
- Species Reactivity
- Human
- Name
- VC (valine-citrulline)
- Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Name
- MMAF (Monomethyl auristatin F)
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
- Anti-TNF (Nerelimomab)-MC-Vc-PAB-MMAE ADC (CAT#: ADC-W-1859)
- Anti-EGFR (clone A1)-Mc-MMAF ADC (CAT#: ADC-W-035)
- Anti-MUC1 (Sontuzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (CAT#: ADC-W-2491)
- Anti-IL17A (Secukinumab)-MC-MMAF ADC (CAT#: ADC-W-1312)
- Anti-RTN4 (Ozanezumab)-SPDB-DM4 ADC (CAT#: ADC-W-1743)
- Anti-FGFR2 (clone 10164)-sulfo-SMCC-DM1 ADC (CAT#: ADC-W-053)
- Anti-CD3E (Pasotuxizumab)-MC-Vc-PAB-MMAE ADC (CAT#: ADC-W-2423)
- Anti-IL9 (Enokizumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (CAT#: ADC-W-1453)
- Anti-MUC1 (Cantuzumab )-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-1614)
- Anti-TNF (Certolizumab pegol)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (CAT#: ADC-W-1849)
Published Data
+ Submit Publications
Scientific Resources
Customer Reviews and FAQs
There are currently no Customer reviews or questions for ADC-W-082. Click the button above to contact us or submit your feedback about this product.
Quick Links
Other Products
Same Linker
Same Payload
Same Target
| CAT# | Product Name | Linker | Payload |
| ADC-AA-048 | Protein G-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-462 | Anti-GPNMB-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-514 | Anti-ERBB2 (Trastuzumab)-VC-DUBA ADC | VC (valine-citrulline) | seco-DUBA (DUocarmycin hydroxyBenzamide Azaindole) |
| ADC-AA-052 | Protein A-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-565 | Anti-EDNRB-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-010 | anti-HIgG(Fc)Fab-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-W-493 | Anti-CD19 (clone huB4)-Mc-MMAF ADC | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-515 | Anti-EGFR (ABT-806)-Mc-MMAF ADC | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-AA-027 | anti-MIgG(Fc)Fab-N-MMAF ADC | Noncleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-W-604 | Anti-FUT3 (clone BR96)-Mc-VC-PABC-MMAF ADC | MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAF (Monomethyl auristatin F) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-573 | Anti-CD70 (clone h1F6239C)-PBD ADC | maleimidocaproyl-valine-alanine | pyrrolobenzodiazepine (PBD) |
| ADC-W-955 | Anti-CD70 (Vorsetuzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
| ADC-W-953 | Anti-CD70 (Vorsetuzumab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-446 | Anti-CD70 (clone h1F6)-Mc-VC-PBD ADC | mc-VC (maleimidocaproyl-valine-citrulline) | pyrrolobenzodiazepine (PBD) dimers |
| ADC-W-452 | Anti-CD70 (clone 1F6)-Mc-MMAF ADC | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
Online Inquiry
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
