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Anti-EDNBR (clone 5E9)-VC-MMAE ADC

Anti-EDNBR (clone 5E9)-VC-MMAE ADC (CAT#: ADC-W-601)

This ADC product is comprised of an anti-EDNRB monoclonal antibody (clone 5E9) conjugated via a VC linker to MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

Product Information
ADC Target
ADC Antibody
ADC Linker
ADC payload drug

Antibody clone #
5E9

Name
EDNRB

Alternative Names
EDNRB; endothelin receptor type B; ETB; ET-B; ETBR; ETRB; HSCR; WS4A; ABCDS; ET-BR; HSCR2; endothelin B receptor; endothelin receptor non-selective type;

Target Entrez Gene ID
1910

Target UniProt ID
P24530

Overview
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Overview
Anti-EDNRB Antibody, clone # 5E9

Clone #
5E9

Species Reactivity
Human

Name
VC (valine-citrulline)

Description
Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

Name
MMAE (Monomethyl auristatin E)

Description
Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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CAMouse™-Fully Human Antibody Generation Platform

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Other Products

Same Target Same Linker Same Payload

CAT#	Product Name	Linker	Payload
ADC-W-536	Anti-EDNRB (endothelin B)-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-565	Anti-EDNRB-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)

CAT#	Product Name	Linker	Payload
ADC-W-514	Anti-ERBB2 (Trastuzumab)-VC-DUBA ADC	VC (valine-citrulline)	seco-DUBA (DUocarmycin hydroxyBenzamide Azaindole)
ADC-W-477	Anti-NECTIN4-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-486	Anti-CD37-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-475	Anti-CA9-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-AA-048	Protein G-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)

CAT#	Product Name	Linker	Payload
ADC-AA-048	Protein G-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-465	Anti-TNFRSF8 (Brentuximab)-VC-PAB-MMAE ADC	VC-PAB (valine-citrulline with PAB)	MMAE (Monomethyl auristatin E)
ADC-W-565	Anti-EDNRB-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-AA-029	anti-MIgG(Fc)Fab-C-MMAE ADC	Cleavable linkers	MMAE (Monomethyl auristatin E)
ADC-AA-003	anti-HIgG(Fc)-C-MMAE ADC	Cleavable linkers	MMAE (Monomethyl auristatin E)

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