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Anti-MUC16-Mc-VC-PABC-MMAE ADC (CAT#: ADC-W-466)

This ADC product is comprised of an Anti-MUC16 antibody conjugated via a Mc-VC-PABC linker to MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Name
  • MUC16
  • Alternative Names
  • CA125
  • Target Entrez Gene ID
  • 94025
  • Overview
  • MUC16 is a Protein Coding gene. Diseases associated with MUC16 include mucinous ovarian cystadenoma and pleural cancer. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.
  • Overview
  • Chimeric Anti-MUC16 Antibody
  • Species Reactivity
  • Human
  • Name
  • MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
  • Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Name
  • MMAE (Monomethyl auristatin E)
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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Same Target Same Linker Same Payload
CAT# Product Name Linker Payload
ADC-W-564 Anti-MUC16-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)
ADC-W-2566 Anti-MUC16 (Sofituzumab)-SPDB-DM4 ADC SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
ADC-W-2568 Anti-MUC16 (Sofituzumab)-MC-Vc-PAB-MMAE ADC MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE
ADC-W-2570 Anti-MUC16 (Sofituzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA
ADC-W-1646 Anti-MUC16 (Oregovomab)-SMCC-DM1 ADC SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
CAT# Product Name Linker Payload
ADC-W-451 Anti-CD70 (clone 1F6)-Mc-VC-PABC-MMAF ADC MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAF (Monomethyl auristatin F)
ADC-W-506 Anti-VTCN1 (clone h1D11)-MC-vc-PABC-MMAE ADC MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E)
ADC-W-455 Anti-MSLN (clone h7D9.v3)-Mc-VC-PABC-MMAE ADC MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E)
ADC-W-619 Anti-MS4A1-Mc-VC-PABC-MMAE ADC MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E)
ADC-W-532 Anti-ITGAE (clone M290)-Mc-VC-PABC-MMAE ADC MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E)
CAT# Product Name Linker Payload
ADC-AA-048 Protein G-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)
ADC-AA-021 anti-MIgG(Fc)-C-MMAE ADC Cleavable linkers MMAE (Monomethyl auristatin E)
ADC-W-499 Anti-SLC34A2 (Lifastuzumab)-VC-MMAE ADC mc-VC-PABC MMAE (Monomethyl auristatin E)
ADC-W-465 Anti-TNFRSF8 (Brentuximab)-VC-PAB-MMAE ADC VC-PAB (valine-citrulline with PAB) MMAE (Monomethyl auristatin E)
ADC-AA-056 Anti-MIgG (clone 187.1)-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)

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